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- W2395264001 endingPage "268" @default.
- W2395264001 startingPage "259" @default.
- W2395264001 abstract "The tumor necrosis factor (TNF) family of cytokines and their receptors regulate various aspects of B cell maturation, survival and function. The closely related ligands BAFF and APRIL bind to two receptors BCMA and TACI and contribute to isotype switching and plasma cell survival. BAFF is also bound by a third receptor, the BAFF-R. Signaling through this receptor is essential for B cell maturation and survival and possibly contributes to antigen-induced proliferation by promoting protein synthesis and metabolic fitness. CD40-mediated signaling is essential for an efficient humoral immune response. A wide spectrum of processes including differentiation, proliferation, and isotype switching is regulated by CD40. In addition, CD40 signaling supports the survival of germinal center B cells and partially protects against Fas-mediated cells death. Fas, also a member of the TNF receptor family, is the main receptor responsible for the elimination of obsolete or potentially harmful germinal center B cells. This article focuses on the role of BAFF-R, TACI, BCMA, CD40, and Fas in activated B cells and cells that have differentiated to germinal center B cells or plasma cells. We discuss the major intracellular signaling pathways activated upon receptor engagement and the functional outcome of these signaling events." @default.
- W2395264001 created "2016-06-24" @default.
- W2395264001 creator A5021302185 @default.
- W2395264001 creator A5044068260 @default.
- W2395264001 date "2016-01-01" @default.
- W2395264001 modified "2023-10-14" @default.
- W2395264001 title "TNF and TNFR Family Members and B Cell Activation" @default.
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