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• W2395264818 abstract "Fluid biopsies potentially offer a minimally invasive alternative to traditional tissue biopsies for the continual monitoring of metastatic cancer. Current established technologies for isolating circulating tumor cells (CTCs) suffer from poor purity and yield and require fixatives that preclude the collection of viable cells for longitudinal analyses of biological function. Antigen specific lysis (ASL) is a rapid, high-purity method of cell isolation based on targeted protective coatings on antigen-presenting cells and lysis depletion of unprotected antigen-negative cells. In ASL, photoinitiators are specifically labeled on cell surfaces that enable subsequent surface-initiated polymerization. Critically, the significant determinants of process yield have yet to be investigated for this emerging technology. In this work, we show that the labeling density of photoinitiators is strongly correlated with the yield of intact cells during ASL by flow cytometry analysis. Results suggest ASL is capable of delivering ∼25% of targeted cells after isolation using traditional antibody labeling approaches. Monomer formulations of two molecular weights of PEG-diacrylate (Mn ∼ 575 and 3500) are examined. The gelation response during ASL polymerization is also investigated via protein microarray analogues on planar glass. Finally, a density threshold of photoinitiator labeling required for protection during lysis is determined for both monomer formulations. These results indicate ASL is a promising technology for high yield CTC isolation for rare-cell function assays and fluid biopsies." @default.
• W2395264818 created "2016-06-24" @default.
• W2395264818 creator A5045668598 @default.
• W2395264818 creator A5063851479 @default.
• W2395264818 date "2016-05-26" @default.
• W2395264818 modified "2023-09-23" @default.
• W2395264818 title "The Role of Surface Receptor Density in Surface-Initiated Polymerizations for Cancer Cell Isolation" @default.
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• W2395264818 doi "https://doi.org/10.1021/acs.langmuir.6b01146" @default.
• W2395264818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5047530" @default.
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• W2395264818 hasPublicationYear "2016" @default.
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