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- W2395285522 abstract "Cell division through proper spindle formation is one of the key puzzles in cell biology. In most mammalian cells, chromosomes spontaneously arrange to achieve a stable bipolar spindle during metaphase which eventually ensures proper segregation of the DNA into the daughter cells. In this paper, we present a robust three-dimensional mechanistic model to investigate the formation and maintenance of a bipolar mitotic spindle in mammalian cells under different physiological constraints. Using realistic parameters, we test spindle viability by measuring the spindle length and studying the chromosomal configuration. The model strikingly predicts a feature of the spindle instability arising from the insufficient intercentrosomal angular separation and impaired sliding of the interpolar microtubules. In addition, our model successfully reproduces chromosomal patterns observed in mammalian cells, when activity of different motor proteins is perturbed." @default.
- W2395285522 created "2016-06-24" @default.
- W2395285522 creator A5018365549 @default.
- W2395285522 creator A5021741801 @default.
- W2395285522 creator A5023857402 @default.
- W2395285522 date "2015-10-28" @default.
- W2395285522 modified "2023-09-24" @default.
- W2395285522 title "Intercentrosomal angular separation during mitosis plays a crucial role for maintaining spindle stability" @default.
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- W2395285522 doi "https://doi.org/10.1103/physreve.92.042714" @default.
- W2395285522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26565279" @default.
- W2395285522 hasPublicationYear "2015" @default.
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