Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395290749> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2395290749 endingPage "42" @default.
- W2395290749 startingPage "S39" @default.
- W2395290749 abstract "The use of bioreductive drugs as an adjunct to radiotherapy in the treatment of cancer is presently being tested in several clinical trials worldwide. We have developed a novel bioreductive compound AQ4N (1,4-bis-¿[2-(dimethylamino-N-oxide)ethyl]amino¿ 5,8-dihydroxy-anthracene-9, 10-dione) which can be reduced to a stable cytotoxic agent AQ4. The anti-tumour efficacy of AQ4N has been studied using male BDF mice bearing the T50/80 tumour. AQ4N in combination with single dose radiation (12 Gy) and also with two fractionated radiation regimens was examined (5 x 3 Gy, one fraction per day; or 10 x 2 Gy fractions, 2 fractions per day with an 8 h interval). Results show that in all combinations tested there was a marked increase in anti-tumour efficacy. This was also found in the single dose regimen for the bioreductive drug tirapazamine (SR 4233; 3-amino-1,2,4-benzotriazine-1, 4-dioxide). Normal tissue toxicity of drug-radiation combinations was measured by assessing function in the eccrine sweat gland of the mouse hind foot. When combined with 10 Gy radiation neither AQ4N nor tirapazamine showed any enhancement of functional loss as compared with radiation alone. This was in contrast to mitomycin C which had a marked effect on the radiation induced functional deficit. In conclusion, in our model, an increase in the therapeutic index was obtained for radiation treatment when either AQ4N or tirapazamine was administered concurrently." @default.
- W2395290749 created "2016-06-24" @default.
- W2395290749 creator A5012823748 @default.
- W2395290749 creator A5037200457 @default.
- W2395290749 creator A5050147131 @default.
- W2395290749 creator A5085066187 @default.
- W2395290749 creator A5086245744 @default.
- W2395290749 creator A5088394651 @default.
- W2395290749 date "1996-07-01" @default.
- W2395290749 modified "2023-09-23" @default.
- W2395290749 title "Evidence for a therapeutic gain when AQ4N or tirapazamine is combined with radiation." @default.
- W2395290749 cites W1989177534 @default.
- W2395290749 cites W2015333502 @default.
- W2395290749 cites W2052907052 @default.
- W2395290749 cites W2063678807 @default.
- W2395290749 cites W2070670105 @default.
- W2395290749 cites W2077439887 @default.
- W2395290749 cites W2094500382 @default.
- W2395290749 cites W2144200477 @default.
- W2395290749 cites W2151738570 @default.
- W2395290749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2150042" @default.
- W2395290749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8763843" @default.
- W2395290749 hasPublicationYear "1996" @default.
- W2395290749 type Work @default.
- W2395290749 sameAs 2395290749 @default.
- W2395290749 citedByCount "13" @default.
- W2395290749 countsByYear W23952907492012 @default.
- W2395290749 countsByYear W23952907492015 @default.
- W2395290749 countsByYear W23952907492022 @default.
- W2395290749 crossrefType "journal-article" @default.
- W2395290749 hasAuthorship W2395290749A5012823748 @default.
- W2395290749 hasAuthorship W2395290749A5037200457 @default.
- W2395290749 hasAuthorship W2395290749A5050147131 @default.
- W2395290749 hasAuthorship W2395290749A5085066187 @default.
- W2395290749 hasAuthorship W2395290749A5086245744 @default.
- W2395290749 hasAuthorship W2395290749A5088394651 @default.
- W2395290749 hasConcept C109316439 @default.
- W2395290749 hasConcept C126322002 @default.
- W2395290749 hasConcept C185592680 @default.
- W2395290749 hasConcept C19831878 @default.
- W2395290749 hasConcept C202751555 @default.
- W2395290749 hasConcept C2776313096 @default.
- W2395290749 hasConcept C2780035454 @default.
- W2395290749 hasConcept C29730261 @default.
- W2395290749 hasConcept C2989005 @default.
- W2395290749 hasConcept C502942594 @default.
- W2395290749 hasConcept C509974204 @default.
- W2395290749 hasConcept C55493867 @default.
- W2395290749 hasConcept C71924100 @default.
- W2395290749 hasConcept C98274493 @default.
- W2395290749 hasConceptScore W2395290749C109316439 @default.
- W2395290749 hasConceptScore W2395290749C126322002 @default.
- W2395290749 hasConceptScore W2395290749C185592680 @default.
- W2395290749 hasConceptScore W2395290749C19831878 @default.
- W2395290749 hasConceptScore W2395290749C202751555 @default.
- W2395290749 hasConceptScore W2395290749C2776313096 @default.
- W2395290749 hasConceptScore W2395290749C2780035454 @default.
- W2395290749 hasConceptScore W2395290749C29730261 @default.
- W2395290749 hasConceptScore W2395290749C2989005 @default.
- W2395290749 hasConceptScore W2395290749C502942594 @default.
- W2395290749 hasConceptScore W2395290749C509974204 @default.
- W2395290749 hasConceptScore W2395290749C55493867 @default.
- W2395290749 hasConceptScore W2395290749C71924100 @default.
- W2395290749 hasConceptScore W2395290749C98274493 @default.
- W2395290749 hasLocation W23952907491 @default.
- W2395290749 hasOpenAccess W2395290749 @default.
- W2395290749 hasPrimaryLocation W23952907491 @default.
- W2395290749 hasRelatedWork W1966573699 @default.
- W2395290749 hasRelatedWork W2008456339 @default.
- W2395290749 hasRelatedWork W2088819306 @default.
- W2395290749 hasRelatedWork W2102348938 @default.
- W2395290749 hasRelatedWork W2146102943 @default.
- W2395290749 hasRelatedWork W2153965661 @default.
- W2395290749 hasRelatedWork W2767233486 @default.
- W2395290749 hasRelatedWork W2899084033 @default.
- W2395290749 hasRelatedWork W3080441546 @default.
- W2395290749 hasRelatedWork W3202769710 @default.
- W2395290749 hasVolume "27" @default.
- W2395290749 isParatext "false" @default.
- W2395290749 isRetracted "false" @default.
- W2395290749 magId "2395290749" @default.
- W2395290749 workType "article" @default.