FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395360971> ?p ?o ?g. }

• W2395360971 endingPage "128" @default.
• W2395360971 startingPage "121" @default.
• W2395360971 abstract "Traditionally, Centella asiatica leaf extracts are used to treat neurodegenerative diseases in India. Centella asiatica is reportedly used to enhance memory and treat dementia, but its promoting effect on neural stem cell differentiation has not been studied yet. In the present study, we investigated whether or not Centella asiatica leaf extracts act on neuronal precursor cells and neuronal cell lines to induce neuronal differentiation, neurite outgrowth, and neuroprotection. The neurogenesis-promoting potential of Centella asiatica leaf extracts was determined by differentiation assay on neural stem cells isolated from mouse embryos and PC12 cell lines. To understand the contribution of specific neural cell types towards increase after Centella asiatica treatment, neural stem cells were differentiated into various neural subtypes and checked by Western blotting using neural cell lineage-specific antibody markers. Neuroprotective activity of Centella asiatica was analyzed in PC12 cells exposed to 100 μM of H2O2. Cell growth was analyzed by MTT assay while cell death was analyzed by Western blotting detection of apoptosis-related proteins. Cells treated with Centella asiatica had significantly longer primary and secondary neurites as well as a higher number of neurites per cell compared to control cells. Expression levels of TUBBIII, TH, NF, and BDNF increased upon Centella asiatica treatment, suggesting that Centella asiatica has a neurogenesis-promoting effect. Centella asiatica also inhibited oxidative stress-induced neural cell damage through regulation of apoptosis- and cell cycle-related proteins. Thus, leaf extracts of Centella asiatica might promote neurogenesis, neuroregeneration, and neuroprotection in the context of neurodegenerative diseases." @default.
• W2395360971 created "2016-06-24" @default.
• W2395360971 creator A5007610160 @default.
• W2395360971 creator A5033946983 @default.
• W2395360971 creator A5069231922 @default.
• W2395360971 date "2015-09-01" @default.
• W2395360971 modified "2023-10-16" @default.
• W2395360971 title "Centella asiatica enhances neurogenesis and protects neuronal cells against H2O2-induced oxidative injury" @default.
• W2395360971 cites W1011518693 @default.
• W2395360971 cites W1557117764 @default.
• W2395360971 cites W1643680178 @default.
• W2395360971 cites W1967987821 @default.
• W2395360971 cites W1972776166 @default.
• W2395360971 cites W1974556508 @default.
• W2395360971 cites W1974766546 @default.
• W2395360971 cites W1977910319 @default.
• W2395360971 cites W1983070786 @default.
• W2395360971 cites W1987051386 @default.
• W2395360971 cites W1988398725 @default.
• W2395360971 cites W1989919097 @default.
• W2395360971 cites W2000304313 @default.
• W2395360971 cites W2021784041 @default.
• W2395360971 cites W2022125304 @default.
• W2395360971 cites W2033327918 @default.
• W2395360971 cites W2037025679 @default.
• W2395360971 cites W2044559314 @default.
• W2395360971 cites W2046847011 @default.
• W2395360971 cites W2050513958 @default.
• W2395360971 cites W2058881098 @default.
• W2395360971 cites W2060550396 @default.
• W2395360971 cites W2065716130 @default.
• W2395360971 cites W2066451338 @default.
• W2395360971 cites W2066886841 @default.
• W2395360971 cites W2074138980 @default.
• W2395360971 cites W2075277546 @default.
• W2395360971 cites W2078945917 @default.
• W2395360971 cites W2094387085 @default.
• W2395360971 cites W2099556643 @default.
• W2395360971 cites W2114703626 @default.
• W2395360971 cites W2124211842 @default.
• W2395360971 cites W2142359416 @default.
• W2395360971 cites W2314613484 @default.
• W2395360971 cites W2336366069 @default.
• W2395360971 doi "https://doi.org/10.12729/jbr.2015.16.3.121" @default.
• W2395360971 hasPublicationYear "2015" @default.
• W2395360971 type Work @default.
• W2395360971 sameAs 2395360971 @default.
• W2395360971 citedByCount "2" @default.
• W2395360971 countsByYear W23953609712022 @default.
• W2395360971 countsByYear W23953609712023 @default.
• W2395360971 crossrefType "journal-article" @default.
• W2395360971 hasAuthorship W2395360971A5007610160 @default.
• W2395360971 hasAuthorship W2395360971A5033946983 @default.
• W2395360971 hasAuthorship W2395360971A5069231922 @default.
• W2395360971 hasConcept C113246987 @default.
• W2395360971 hasConcept C136834591 @default.
• W2395360971 hasConcept C1491633281 @default.
• W2395360971 hasConcept C190283241 @default.
• W2395360971 hasConcept C202751555 @default.
• W2395360971 hasConcept C25498285 @default.
• W2395360971 hasConcept C2779077069 @default.
• W2395360971 hasConcept C28328180 @default.
• W2395360971 hasConcept C31573885 @default.
• W2395360971 hasConcept C4746552 @default.
• W2395360971 hasConcept C53227056 @default.
• W2395360971 hasConcept C55493867 @default.
• W2395360971 hasConcept C556039675 @default.
• W2395360971 hasConcept C59822182 @default.
• W2395360971 hasConcept C62112901 @default.
• W2395360971 hasConcept C71924100 @default.
• W2395360971 hasConcept C86803240 @default.
• W2395360971 hasConcept C95444343 @default.
• W2395360971 hasConcept C98274493 @default.
• W2395360971 hasConceptScore W2395360971C113246987 @default.
• W2395360971 hasConceptScore W2395360971C136834591 @default.
• W2395360971 hasConceptScore W2395360971C1491633281 @default.
• W2395360971 hasConceptScore W2395360971C190283241 @default.
• W2395360971 hasConceptScore W2395360971C202751555 @default.
• W2395360971 hasConceptScore W2395360971C25498285 @default.
• W2395360971 hasConceptScore W2395360971C2779077069 @default.
• W2395360971 hasConceptScore W2395360971C28328180 @default.
• W2395360971 hasConceptScore W2395360971C31573885 @default.
• W2395360971 hasConceptScore W2395360971C4746552 @default.
• W2395360971 hasConceptScore W2395360971C53227056 @default.
• W2395360971 hasConceptScore W2395360971C55493867 @default.
• W2395360971 hasConceptScore W2395360971C556039675 @default.
• W2395360971 hasConceptScore W2395360971C59822182 @default.
• W2395360971 hasConceptScore W2395360971C62112901 @default.
• W2395360971 hasConceptScore W2395360971C71924100 @default.
• W2395360971 hasConceptScore W2395360971C86803240 @default.
• W2395360971 hasConceptScore W2395360971C95444343 @default.
• W2395360971 hasConceptScore W2395360971C98274493 @default.
• W2395360971 hasFunder F4320322030 @default.
• W2395360971 hasIssue "3" @default.
• W2395360971 hasLocation W23953609711 @default.
• W2395360971 hasOpenAccess W2395360971 @default.
• W2395360971 hasPrimaryLocation W23953609711 @default.
• W2395360971 hasRelatedWork W1234816868 @default.

• next