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- W2395404635 abstract "OBJECTIVE: To investigate the expression of gonadotropin-releasing hormone receptor (GnRH-R) mRNA in the endometrium of normal and endometrial cancer uterus. METHODS: In situ hybridization was used to detect the expression of GnRH-R mRNA in 23 cases of normal endometrium in hyperplasic phase, 30 cases of normal endometrium in secretory phase, and 30 cases of endometrium from endometrial cancer. RESULTS: The results showed that GnRH-R mRNA was expressed in the cytoplasm of endometrium of normal and endometrial cancer uterus. There was no expression in the nuclei. There was no significant difference (P > 0.05) in the expression rate between the hyperplasic phase (17%, 4/23) and the secretory phase (17%, 5/30) in normal uterus. The expression rate in endometrial cancer was 40% (12/30), which was significantly higher than normal endometrium (P < 0.05). CONCLUSIONS: The data demonstrates that GnRH may act directly on endometrium. GnRH-R is highly expressed in the endometrium of endometrial cancer." @default.
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- W2395404635 date "2006-05-01" @default.
- W2395404635 modified "2023-09-27" @default.
- W2395404635 title "[Expression and significance of gonadotropin-releasing hormone receptor in the endometrium of normal and endometrial cancer uterus]." @default.
- W2395404635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16762189" @default.
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