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• W2395418446 abstract "ABSTRACT Objective Socioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio. We hypothesized that participants with a lower income would have higher E/N ratios and lower CD4/CD8 ratios compared with participants with a higher income, and that these associations would be partially mediated by elevated cytomegalovirus (CMV) IgG antibody levels, a virus implicated in aging and clonal expansion of T cells. Methods Data were from 79 individuals who participated in the population-based Detroit Neighborhood Health Study. We used linear regression to quantify the association between a $10,000 decrease in income and each ratio outcome. Results After adjustment for age, sex, race, smoking, medication use, and lifetime history of mental health conditions, lower income was associated with a 0.41 (95% confidence interval = 0.09–0.72) log-unit increase in the CD4 E/N ratio and a 0.20 (95% confidence interval = 0.02–0.39) log-unit increase in the CD8 E/N ratio. CMV immunoglobulin G antibody level partially mediated these associations. Conclusions Our study suggests that low socioeconomic status is associated with immunological aging as measured by the E/N ratio and that impaired immune control of CMV may partially mediate these associations." @default.
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• W2395418446 date "2016-07-01" @default.
• W2395418446 modified "2023-10-16" @default.
• W2395418446 title "Income and Markers of Immunological Cellular Aging" @default.
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• W2395418446 doi "https://doi.org/10.1097/psy.0000000000000320" @default.
• W2395418446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4927391" @default.
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