FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395473492> ?p ?o ?g. }

• W2395473492 endingPage "150" @default.
• W2395473492 startingPage "143" @default.
• W2395473492 abstract "Liposarcoma (LPS) is one of the most prevalent soft tissue sarcomas. LPS shows a poor response to radiation and chemotherapy. The causes of death in patients with LPS include locally recurrent and metastatic disease. We sought to examine novel gene mutations and pathways in primary and matched recurrent LPSs to identify potential therapeutic targets. We conducted a high-throughput analysis of 238 known mutations in 19 oncogenes using Sequenom MassARRAY technology. Nucleic acids were extracted from 19 primary and recurrent LPS samples, encompassing 9 dedifferentiated LPSs (DDLPS), 9 myxoid/round cell LPSs, and 1 pleomorphic LPS. Mutation screening revealed missense mutations in 21.1% (4/19) of the LPS specimens, including 4 different genes (FGFR1, FGFR3, PIK3CA, and KIT). Based on histologic subtypes, 22.2% DDLPS (2/9) and 22.2% myxoid cell LPS (2/9) contained gene mutations. Specifically, 3 (23.1%) of 13 primary tumors harbored mutations. Furthermore, although gene mutations were identified in 1 (11.1%) of 9 recurrent LPS samples, the difference between the primary and the recurrence was not statistically significant. Analysis of patient survival data indicated that patients harboring FGFR1/3 mutations experienced reduced overall survival (P<.05). Despite the limited number of samples, our findings provide the first evidence of FGFR1/3 mutations in DDLPS, which were associated with poor clinical outcomes. The FGFR pathway may play an important role in the development and progression of DDLPS and warrants further investigation; moreover, PIK3CA mutation is a common event (11.1%) in myxoid cell LPS." @default.
• W2395473492 created "2016-06-24" @default.
• W2395473492 creator A5006404930 @default.
• W2395473492 creator A5038699958 @default.
• W2395473492 creator A5053985637 @default.
• W2395473492 creator A5055410323 @default.
• W2395473492 creator A5060381379 @default.
• W2395473492 creator A5071037763 @default.
• W2395473492 creator A5078007778 @default.
• W2395473492 creator A5081844561 @default.
• W2395473492 date "2016-09-01" @default.
• W2395473492 modified "2023-09-27" @default.
• W2395473492 title "Oncogene mutation profiling reveals poor prognosis associated with FGFR1/3 mutation in liposarcoma" @default.
• W2395473492 cites W1565936160 @default.
• W2395473492 cites W1603547407 @default.
• W2395473492 cites W1986308239 @default.
• W2395473492 cites W1986440552 @default.
• W2395473492 cites W1988476050 @default.
• W2395473492 cites W1994487360 @default.
• W2395473492 cites W2000045451 @default.
• W2395473492 cites W2000107163 @default.
• W2395473492 cites W2016334273 @default.
• W2395473492 cites W2017117404 @default.
• W2395473492 cites W2023568503 @default.
• W2395473492 cites W2043276864 @default.
• W2395473492 cites W2043407242 @default.
• W2395473492 cites W2051146173 @default.
• W2395473492 cites W2064107732 @default.
• W2395473492 cites W2086797990 @default.
• W2395473492 cites W2096785399 @default.
• W2395473492 cites W2112359031 @default.
• W2395473492 cites W2118155696 @default.
• W2395473492 cites W2123359711 @default.
• W2395473492 cites W2125972676 @default.
• W2395473492 cites W2129172946 @default.
• W2395473492 cites W2131117209 @default.
• W2395473492 cites W2139536022 @default.
• W2395473492 cites W2144497460 @default.
• W2395473492 cites W2319559554 @default.
• W2395473492 cites W2768240065 @default.
• W2395473492 doi "https://doi.org/10.1016/j.humpath.2016.05.006" @default.
• W2395473492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27237367" @default.
• W2395473492 hasPublicationYear "2016" @default.
• W2395473492 type Work @default.
• W2395473492 sameAs 2395473492 @default.
• W2395473492 citedByCount "13" @default.
• W2395473492 countsByYear W23954734922018 @default.
• W2395473492 countsByYear W23954734922019 @default.
• W2395473492 countsByYear W23954734922020 @default.
• W2395473492 countsByYear W23954734922021 @default.
• W2395473492 countsByYear W23954734922022 @default.
• W2395473492 countsByYear W23954734922023 @default.
• W2395473492 crossrefType "journal-article" @default.
• W2395473492 hasAuthorship W2395473492A5006404930 @default.
• W2395473492 hasAuthorship W2395473492A5038699958 @default.
• W2395473492 hasAuthorship W2395473492A5053985637 @default.
• W2395473492 hasAuthorship W2395473492A5055410323 @default.
• W2395473492 hasAuthorship W2395473492A5060381379 @default.
• W2395473492 hasAuthorship W2395473492A5071037763 @default.
• W2395473492 hasAuthorship W2395473492A5078007778 @default.
• W2395473492 hasAuthorship W2395473492A5081844561 @default.
• W2395473492 hasConcept C104317684 @default.
• W2395473492 hasConcept C111829193 @default.
• W2395473492 hasConcept C142724271 @default.
• W2395473492 hasConcept C170493617 @default.
• W2395473492 hasConcept C2778256501 @default.
• W2395473492 hasConcept C2779568860 @default.
• W2395473492 hasConcept C49418065 @default.
• W2395473492 hasConcept C501734568 @default.
• W2395473492 hasConcept C502942594 @default.
• W2395473492 hasConcept C54355233 @default.
• W2395473492 hasConcept C71924100 @default.
• W2395473492 hasConcept C74373430 @default.
• W2395473492 hasConcept C75563809 @default.
• W2395473492 hasConcept C7602840 @default.
• W2395473492 hasConcept C86803240 @default.
• W2395473492 hasConceptScore W2395473492C104317684 @default.
• W2395473492 hasConceptScore W2395473492C111829193 @default.
• W2395473492 hasConceptScore W2395473492C142724271 @default.
• W2395473492 hasConceptScore W2395473492C170493617 @default.
• W2395473492 hasConceptScore W2395473492C2778256501 @default.
• W2395473492 hasConceptScore W2395473492C2779568860 @default.
• W2395473492 hasConceptScore W2395473492C49418065 @default.
• W2395473492 hasConceptScore W2395473492C501734568 @default.
• W2395473492 hasConceptScore W2395473492C502942594 @default.
• W2395473492 hasConceptScore W2395473492C54355233 @default.
• W2395473492 hasConceptScore W2395473492C71924100 @default.
• W2395473492 hasConceptScore W2395473492C74373430 @default.
• W2395473492 hasConceptScore W2395473492C75563809 @default.
• W2395473492 hasConceptScore W2395473492C7602840 @default.
• W2395473492 hasConceptScore W2395473492C86803240 @default.
• W2395473492 hasLocation W23954734921 @default.
• W2395473492 hasLocation W23954734922 @default.
• W2395473492 hasOpenAccess W2395473492 @default.
• W2395473492 hasPrimaryLocation W23954734921 @default.
• W2395473492 hasRelatedWork W1985062025 @default.
• W2395473492 hasRelatedWork W2060684927 @default.
• W2395473492 hasRelatedWork W2070185078 @default.

• next