Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395478284> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2395478284 endingPage "8, 244" @default.
- W2395478284 startingPage "223" @default.
- W2395478284 abstract "To observe the effect of acupuncture on p130 expression in neocortex and hippocampus of Senescence Accelerated Mouse/Prone (SAMP) 10 so as to explore its underlying molecular mechanism in treating dementia and aging-related diseases.Thirty SAMP 10 were randomly divided into model, acupuncture, and non-acupoint groups with 10 cases in each, and 10 SAM/Resistant (SAMR)1 were used as normal control group. The needle manipulation of Yi Qi Tiao Xue, Fu Ben Pei Yuan (Reinforcing qi and blood, and strengthening the body resistance) was applied to Shanzhong (CV 17), Zhongwan (CV 12), Qihai (CV 16), Xuehai (SP 10) and Zusanli (ST 36), once daily for two weeks. p130 expression of neocortex and hippocampus was assayed by western blotting technique.In SAMR 1 control group, p 130 expression in the neocortex and hippocampus exhibited an age-related stable upregulation from month 2 to 12, being significantly from the 6= month (neocortex) on and 8th month (hippocampus) on respectively (P < 0.05, 0.01). In SAMP 10 group, hippocampal and neocortical p130 expression exhibited an age-related downregulation change in the same period, fluctuating in about 6th month (downregulated remarkably in hippocampus, P < 0.01; upregulated markedly in neocortex, P < 0.01). In comparison with SAMR 1 (8 months old) group, p130 expression in hippocampus in SAMP 10 model group was upregulated significantly (P < 0.05); while that in neocortex downregulated considerably (P < 0.05). The expression of p 130 in neocortex in acupoint-acupuncture group was significantly higher than that in SAMP 10 model and non-acupoint acupuncture groups (P < 0.05). No significant differences were found between acupoint- and non-acupoint acupuncture groups in hippocampal p 130 expression, and between non-acupoint acupuncture and SAMP 10 model groups in neocortical p 130 expression (P > 0.05).Along with the increase of aging, p 130 expression in both hippocampus and neocortex increases gradually in SAMR 1, while decreases in SAMP 10, in spite of fluctuating at month 6 in age. Acupuncture can beneficially regulate the aberrant expression of p130 in neocortex of 8-month-old SAMP 10." @default.
- W2395478284 created "2016-06-24" @default.
- W2395478284 creator A5007038205 @default.
- W2395478284 creator A5042649765 @default.
- W2395478284 creator A5083566143 @default.
- W2395478284 date "2008-08-01" @default.
- W2395478284 modified "2023-09-29" @default.
- W2395478284 title "[Age-related changes of p130 expression in hippocampus and cerebral cortex and effects of acupuncture in SAMP 10]." @default.
- W2395478284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18928112" @default.
- W2395478284 hasPublicationYear "2008" @default.
- W2395478284 type Work @default.
- W2395478284 sameAs 2395478284 @default.
- W2395478284 citedByCount "1" @default.
- W2395478284 countsByYear W23954782842019 @default.
- W2395478284 crossrefType "journal-article" @default.
- W2395478284 hasAuthorship W2395478284A5007038205 @default.
- W2395478284 hasAuthorship W2395478284A5042649765 @default.
- W2395478284 hasAuthorship W2395478284A5083566143 @default.
- W2395478284 hasConcept C104317684 @default.
- W2395478284 hasConcept C118552586 @default.
- W2395478284 hasConcept C126322002 @default.
- W2395478284 hasConcept C127561419 @default.
- W2395478284 hasConcept C134018914 @default.
- W2395478284 hasConcept C142724271 @default.
- W2395478284 hasConcept C148762608 @default.
- W2395478284 hasConcept C15744967 @default.
- W2395478284 hasConcept C169760540 @default.
- W2395478284 hasConcept C204787440 @default.
- W2395478284 hasConcept C2776202274 @default.
- W2395478284 hasConcept C2777222312 @default.
- W2395478284 hasConcept C2777348757 @default.
- W2395478284 hasConcept C2779504368 @default.
- W2395478284 hasConcept C2781041448 @default.
- W2395478284 hasConcept C2781161787 @default.
- W2395478284 hasConcept C55493867 @default.
- W2395478284 hasConcept C56837625 @default.
- W2395478284 hasConcept C71924100 @default.
- W2395478284 hasConcept C86803240 @default.
- W2395478284 hasConceptScore W2395478284C104317684 @default.
- W2395478284 hasConceptScore W2395478284C118552586 @default.
- W2395478284 hasConceptScore W2395478284C126322002 @default.
- W2395478284 hasConceptScore W2395478284C127561419 @default.
- W2395478284 hasConceptScore W2395478284C134018914 @default.
- W2395478284 hasConceptScore W2395478284C142724271 @default.
- W2395478284 hasConceptScore W2395478284C148762608 @default.
- W2395478284 hasConceptScore W2395478284C15744967 @default.
- W2395478284 hasConceptScore W2395478284C169760540 @default.
- W2395478284 hasConceptScore W2395478284C204787440 @default.
- W2395478284 hasConceptScore W2395478284C2776202274 @default.
- W2395478284 hasConceptScore W2395478284C2777222312 @default.
- W2395478284 hasConceptScore W2395478284C2777348757 @default.
- W2395478284 hasConceptScore W2395478284C2779504368 @default.
- W2395478284 hasConceptScore W2395478284C2781041448 @default.
- W2395478284 hasConceptScore W2395478284C2781161787 @default.
- W2395478284 hasConceptScore W2395478284C55493867 @default.
- W2395478284 hasConceptScore W2395478284C56837625 @default.
- W2395478284 hasConceptScore W2395478284C71924100 @default.
- W2395478284 hasConceptScore W2395478284C86803240 @default.
- W2395478284 hasIssue "4" @default.
- W2395478284 hasLocation W23954782841 @default.
- W2395478284 hasOpenAccess W2395478284 @default.
- W2395478284 hasPrimaryLocation W23954782841 @default.
- W2395478284 hasRelatedWork W2221703441 @default.
- W2395478284 hasRelatedWork W2333156522 @default.
- W2395478284 hasRelatedWork W2353119149 @default.
- W2395478284 hasRelatedWork W2354483473 @default.
- W2395478284 hasRelatedWork W2355037844 @default.
- W2395478284 hasRelatedWork W2357485503 @default.
- W2395478284 hasRelatedWork W2359274907 @default.
- W2395478284 hasRelatedWork W2364621154 @default.
- W2395478284 hasRelatedWork W2364904180 @default.
- W2395478284 hasRelatedWork W2368076186 @default.
- W2395478284 hasRelatedWork W2373948528 @default.
- W2395478284 hasRelatedWork W2378816586 @default.
- W2395478284 hasRelatedWork W2380629907 @default.
- W2395478284 hasRelatedWork W2380654011 @default.
- W2395478284 hasRelatedWork W2382796193 @default.
- W2395478284 hasRelatedWork W2391194391 @default.
- W2395478284 hasRelatedWork W3006326979 @default.
- W2395478284 hasRelatedWork W3031843287 @default.
- W2395478284 hasRelatedWork W3032116725 @default.
- W2395478284 hasRelatedWork W3046003343 @default.
- W2395478284 hasVolume "33" @default.
- W2395478284 isParatext "false" @default.
- W2395478284 isRetracted "false" @default.
- W2395478284 magId "2395478284" @default.
- W2395478284 workType "article" @default.