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- W2395509344 endingPage "2060" @default.
- W2395509344 startingPage "2048" @default.
- W2395509344 abstract "Abstract The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro‐oncogenic, typically depending on the cellular context. Squamous cell carcinoma ( SCC ) is a cancer of the squamous cell, which can occur in diverse human tissues. SCC s are one of the most frequent human malignancies for which the pathologic mechanisms remain elusive. Recent genomic analysis of diverse SCC s identified marked levels of mutations in NOTCH 1 , implicating Notch signaling pathways in the pathogenesis of SCC s. In this review, evidences highlighting NOTCH 's role in different types of SCC s are summarized. Moreover, based on accumulating structural information of the NOTCH receptor, the functional consequences of NOTCH 1 gene mutations identified from diverse SCC s are analyzed, emphasizing loss of function of Notch in these cancers. Finally, we discuss the convergent view on an intriguing possibility that Notch may function as tumor suppressor in SCC s across different tissues. These mechanistic insights into Notch signaling pathways will help to guide the research of SCC s and development of therapeutic strategies for these cancers." @default.
- W2395509344 created "2016-06-24" @default.
- W2395509344 creator A5019215658 @default.
- W2395509344 creator A5023259904 @default.
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- W2395509344 creator A5065635453 @default.
- W2395509344 creator A5065738445 @default.
- W2395509344 creator A5091589432 @default.
- W2395509344 date "2016-05-26" @default.
- W2395509344 modified "2023-10-14" @default.
- W2395509344 title "Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?" @default.
- W2395509344 cites W1516255381 @default.
- W2395509344 cites W1639582946 @default.
- W2395509344 cites W1660631781 @default.
- W2395509344 cites W1964083798 @default.
- W2395509344 cites W1968226123 @default.
- W2395509344 cites W1975771868 @default.
- W2395509344 cites W1977464187 @default.
- W2395509344 cites W1979627083 @default.
- W2395509344 cites W1980393724 @default.
- W2395509344 cites W1981646010 @default.
- W2395509344 cites W1981823569 @default.
- W2395509344 cites W1982547197 @default.
- W2395509344 cites W1986241711 @default.
- W2395509344 cites W1990956554 @default.
- W2395509344 cites W1991769905 @default.
- W2395509344 cites W1993358791 @default.
- W2395509344 cites W1994761823 @default.
- W2395509344 cites W1995004385 @default.
- W2395509344 cites W1997801717 @default.
- W2395509344 cites W2000589976 @default.
- W2395509344 cites W2004637409 @default.
- W2395509344 cites W2005204942 @default.
- W2395509344 cites W2010807493 @default.
- W2395509344 cites W2013898564 @default.
- W2395509344 cites W2018339347 @default.
- W2395509344 cites W2019007505 @default.
- W2395509344 cites W2023575200 @default.
- W2395509344 cites W2024902613 @default.
- W2395509344 cites W2025027059 @default.
- W2395509344 cites W2026595359 @default.
- W2395509344 cites W2026890415 @default.
- W2395509344 cites W2028729817 @default.
- W2395509344 cites W2037290810 @default.
- W2395509344 cites W2038824361 @default.
- W2395509344 cites W2049280705 @default.
- W2395509344 cites W2052165202 @default.
- W2395509344 cites W2053467415 @default.
- W2395509344 cites W2054606083 @default.
- W2395509344 cites W2058734213 @default.
- W2395509344 cites W2061446835 @default.
- W2395509344 cites W2062084323 @default.
- W2395509344 cites W2062312459 @default.
- W2395509344 cites W2064403984 @default.
- W2395509344 cites W2066877759 @default.
- W2395509344 cites W2067611765 @default.
- W2395509344 cites W2077883779 @default.
- W2395509344 cites W2078744748 @default.
- W2395509344 cites W2082195162 @default.
- W2395509344 cites W2086059239 @default.
- W2395509344 cites W2088720735 @default.
- W2395509344 cites W2089663915 @default.
- W2395509344 cites W2092845380 @default.
- W2395509344 cites W2093368670 @default.
- W2395509344 cites W2098503611 @default.
- W2395509344 cites W2102767758 @default.
- W2395509344 cites W2104241613 @default.
- W2395509344 cites W2108060871 @default.
- W2395509344 cites W2108491241 @default.
- W2395509344 cites W2109380828 @default.
- W2395509344 cites W2110947069 @default.
- W2395509344 cites W2114715773 @default.
- W2395509344 cites W2116236493 @default.
- W2395509344 cites W2116965161 @default.
- W2395509344 cites W2118109822 @default.
- W2395509344 cites W2118935254 @default.
- W2395509344 cites W2128282088 @default.
- W2395509344 cites W2128537223 @default.
- W2395509344 cites W2128961154 @default.
- W2395509344 cites W2132268436 @default.
- W2395509344 cites W2133943800 @default.
- W2395509344 cites W2134668392 @default.
- W2395509344 cites W2135247615 @default.
- W2395509344 cites W2135763107 @default.
- W2395509344 cites W2137662527 @default.
- W2395509344 cites W2139230654 @default.
- W2395509344 cites W2140357331 @default.
- W2395509344 cites W2143723854 @default.
- W2395509344 cites W2147014402 @default.
- W2395509344 cites W2150047753 @default.
- W2395509344 cites W2152563905 @default.
- W2395509344 cites W2153558905 @default.
- W2395509344 cites W2155475637 @default.
- W2395509344 cites W2156378083 @default.
- W2395509344 cites W2157092908 @default.
- W2395509344 cites W2159498952 @default.
- W2395509344 cites W2161541244 @default.
- W2395509344 cites W2166269098 @default.