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- W2395541288 abstract "Objective To determine the incidence of azoospermia factor (AZF) microdeletions of Y chromosome in male infertility and to investigate the mechanism of sex-determining region Y (SRY) in sex differentiation. Methods The microdeletion of AZF was detected by multiplex polymerase chain reaction (PCR) using Y-chromosome specific sequence tagged sites (STSs), and SRY was analyzed by PCR and sequencing. Results There were 100 cases with AZF microdeletion and the ratio of AZF microdeletion was 6.8% over all 1 474 cases. The ratios of AZF microdeletion of azoospermia group and severe oligozoospermia group were 9.0% and 7.1%, respectively, which was significantly different from oligozoospermia group (P Conclusion Deletions in AZF region of Y chromosome are specific with diagnoses with spermatogenesis disorder. Deletions of sY152, sY239, sY243, sY254 and sY255 occur the most frequently. SRY was an important candidate gene of testis-determining factor (TDF) gene." @default.
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- W2395541288 date "2013-06-01" @default.
- W2395541288 modified "2023-09-26" @default.
- W2395541288 title "Investigation on Azoospermia Factor (AZF) Microdeletion and Sex-determining Region Y (SRY) of the Y Chromosome in Male Infertility" @default.
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- W2395541288 doi "https://doi.org/10.7669/j.issn.1001-7844.2013.02.0088" @default.
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