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- W2395612161 abstract "Abstract Platelets are essential components of hemostasis. Due to a plethora of factors released on activation, platelet functions are also connected to tumor growth, notably by acting on angiogenesis. It is now well recognized that major roles of platelets in the poor outcome of cancer patients occurs during hematogenous dissemination of cancer cells. In this review, we describe recent insights into the molecular mechanisms supporting the prometastatic activity of platelets. Platelets have been shown to promote survival of circulating tumor cells (CTCs) in the bloodstream by conferring resistance to the shear stress and attack from natural killer cells. Recently, platelets were found to promote and/or maintain the state of epithelial to mesenchymal transition on CTCs through platelet secretion of transforming growth factor β in response to CTC activation. At a later stage in the metastatic process, platelets promote extravasation and establishment of metastatic cells in distant organs as observed in bone. This particular environment is also the site of hematopoiesis, megakaryocytopoiesis, and platelet production. Increasing the number of megakaryocytes (MKs) in the bone marrow results in a high bone mass phenotype and inhibits skeletal metastasis formation of prostate cancer cells. As a result of their specific location in vascular niches in the bone marrow, MK activity might contribute to the “seed and soil” suitability between CTCs and bone. In conclusion, recent findings have made a great advance in our knowledge on how platelets contribute to the metastatic dissemination of cancer cells and that may support the development of new antimetastasis therapies." @default.
- W2395612161 created "2016-06-24" @default.
- W2395612161 creator A5011125687 @default.
- W2395612161 creator A5020261943 @default.
- W2395612161 date "2016-07-07" @default.
- W2395612161 modified "2023-10-16" @default.
- W2395612161 title "Metastasis: new functional implications of platelets and megakaryocytes" @default.
- W2395612161 cites W1526662853 @default.
- W2395612161 cites W1554780345 @default.
- W2395612161 cites W1710493764 @default.
- W2395612161 cites W1892828661 @default.
- W2395612161 cites W1906566368 @default.
- W2395612161 cites W1958040920 @default.
- W2395612161 cites W1964081206 @default.
- W2395612161 cites W1968519475 @default.
- W2395612161 cites W1968628080 @default.
- W2395612161 cites W1971365462 @default.
- W2395612161 cites W1972561843 @default.
- W2395612161 cites W1976526796 @default.
- W2395612161 cites W1979845766 @default.
- W2395612161 cites W1983600360 @default.
- W2395612161 cites W1984783217 @default.
- W2395612161 cites W1984952437 @default.
- W2395612161 cites W1985473224 @default.
- W2395612161 cites W1987168967 @default.
- W2395612161 cites W1990313926 @default.
- W2395612161 cites W1992977955 @default.
- W2395612161 cites W1995601334 @default.
- W2395612161 cites W1996852865 @default.
- W2395612161 cites W2003213153 @default.
- W2395612161 cites W2009863423 @default.
- W2395612161 cites W2012247886 @default.
- W2395612161 cites W2013109407 @default.
- W2395612161 cites W2016741520 @default.
- W2395612161 cites W2018038784 @default.
- W2395612161 cites W2020019411 @default.
- W2395612161 cites W2021065306 @default.
- W2395612161 cites W2023322357 @default.
- W2395612161 cites W2025240578 @default.
- W2395612161 cites W2035362880 @default.
- W2395612161 cites W2038939944 @default.
- W2395612161 cites W2041349540 @default.
- W2395612161 cites W2043166238 @default.
- W2395612161 cites W2047536555 @default.
- W2395612161 cites W2050992261 @default.
- W2395612161 cites W2052047252 @default.
- W2395612161 cites W2057719162 @default.
- W2395612161 cites W2058689113 @default.
- W2395612161 cites W2059424994 @default.
- W2395612161 cites W2062265555 @default.
- W2395612161 cites W2065346142 @default.
- W2395612161 cites W2074617005 @default.
- W2395612161 cites W2075059692 @default.
- W2395612161 cites W2079323372 @default.
- W2395612161 cites W2079629625 @default.
- W2395612161 cites W2082239705 @default.
- W2395612161 cites W2082679230 @default.
- W2395612161 cites W2088001386 @default.
- W2395612161 cites W2091977407 @default.
- W2395612161 cites W2093228291 @default.
- W2395612161 cites W2093422593 @default.
- W2395612161 cites W2096597075 @default.
- W2395612161 cites W2097739264 @default.
- W2395612161 cites W2099380050 @default.
- W2395612161 cites W2111191978 @default.
- W2395612161 cites W2116072433 @default.
- W2395612161 cites W2124422993 @default.
- W2395612161 cites W2135463143 @default.
- W2395612161 cites W2150531719 @default.
- W2395612161 cites W2152986140 @default.
- W2395612161 cites W2154778175 @default.
- W2395612161 cites W2155066067 @default.
- W2395612161 cites W2158134782 @default.
- W2395612161 cites W2159674815 @default.
- W2395612161 cites W2160816795 @default.
- W2395612161 cites W2164375681 @default.
- W2395612161 cites W2165200432 @default.
- W2395612161 cites W2167494200 @default.
- W2395612161 cites W2167664841 @default.
- W2395612161 cites W2206702622 @default.
- W2395612161 cites W2207725031 @default.
- W2395612161 cites W2230842386 @default.
- W2395612161 cites W2354972079 @default.
- W2395612161 cites W251182164 @default.
- W2395612161 cites W4236053983 @default.
- W2395612161 cites W52860441 @default.
- W2395612161 doi "https://doi.org/10.1182/blood-2016-01-636399" @default.
- W2395612161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27154188" @default.
- W2395612161 hasPublicationYear "2016" @default.
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