FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395641346> ?p ?o ?g. }

• W2395641346 endingPage "76" @default.
• W2395641346 startingPage "64" @default.
• W2395641346 abstract "Morphine is commonly used in neonates with hypothermic ischemic encephalopathy (HIE) during therapeutic hypothermia to provide comfort and analgesia. However, pharmacokinetic data to support morphine dosing in this vulnerable population are lacking. A prospective, 2-center clinical pharmacokinetic study of morphine was conducted in 20 neonates (birthweight, 1.82-5.3 kg) with HIE receiving hypothermia. Morphine dosing was per standard of care at each center. Morphine and glucuronide metabolites (morphine-3-glucuronide and morphine-6-gluronide) were measured via a validated dried blood spot liquid chromatography-tandem mass spectrometry assay. From the available concentration data (n = 106 for morphine; n = 106 for each metabolite), a population pharmacokinetic model was developed using nonlinear mixed-effects modeling. The clearance of morphine and glucuronide metabolites was best predicted by birthweight allometrically scaled using an exponent of 1.23. In addition, the clearance of each glucuronide metabolite was influenced by serum creatinine. No other significant predictors of clearance or volume of distribution were found. For a 3.5-kg neonate, morphine clearance was 0.77 L/h (CV, 48%), and the steady-state volume of distribution was 8.0 L (CV, 49%). Compared with previous studies in full-term newborns without HIE, morphine clearance was markedly lower. Dosing strategies customized for this vulnerable population will be needed. Applying the final population pharmacokinetic model, repeated Monte Carlo simulations (n = 1000 per simulation) were performed to evaluate various morphine dosing strategies that optimized achievement of morphine concentrations between 10 and 40 ng/mL. An optimized morphine loading dose of 50 μg/kg followed by a continuous infusion of 5 μg/kg/h was predicted across birthweights." @default.
• W2395641346 created "2016-06-24" @default.
• W2395641346 creator A5035285777 @default.
• W2395641346 creator A5051509877 @default.
• W2395641346 creator A5065118732 @default.
• W2395641346 creator A5076419453 @default.
• W2395641346 creator A5076597174 @default.
• W2395641346 creator A5079478687 @default.
• W2395641346 date "2016-06-26" @default.
• W2395641346 modified "2023-10-05" @default.
• W2395641346 title "Decreased Morphine Clearance in Neonates With Hypoxic Ischemic Encephalopathy Receiving Hypothermia" @default.
• W2395641346 cites W1438714583 @default.
• W2395641346 cites W1447172726 @default.
• W2395641346 cites W1507278289 @default.
• W2395641346 cites W1872204733 @default.
• W2395641346 cites W1969152400 @default.
• W2395641346 cites W1972576782 @default.
• W2395641346 cites W1975348053 @default.
• W2395641346 cites W1977719679 @default.
• W2395641346 cites W1985848675 @default.
• W2395641346 cites W1989683890 @default.
• W2395641346 cites W1993554330 @default.
• W2395641346 cites W1996565727 @default.
• W2395641346 cites W1999521622 @default.
• W2395641346 cites W2010365552 @default.
• W2395641346 cites W2016619395 @default.
• W2395641346 cites W2017572901 @default.
• W2395641346 cites W2017632705 @default.
• W2395641346 cites W2035245728 @default.
• W2395641346 cites W2045883317 @default.
• W2395641346 cites W2055363899 @default.
• W2395641346 cites W2056905562 @default.
• W2395641346 cites W2062236764 @default.
• W2395641346 cites W2063049671 @default.
• W2395641346 cites W2063636286 @default.
• W2395641346 cites W2075435606 @default.
• W2395641346 cites W2081871856 @default.
• W2395641346 cites W2087536686 @default.
• W2395641346 cites W2092840913 @default.
• W2395641346 cites W2098951649 @default.
• W2395641346 cites W2107073476 @default.
• W2395641346 cites W2111800786 @default.
• W2395641346 cites W2113837639 @default.
• W2395641346 cites W2120416054 @default.
• W2395641346 cites W2121615260 @default.
• W2395641346 cites W2122527560 @default.
• W2395641346 cites W2129809334 @default.
• W2395641346 cites W2135122869 @default.
• W2395641346 cites W2154634960 @default.
• W2395641346 cites W2164127547 @default.
• W2395641346 cites W2170420560 @default.
• W2395641346 cites W2171142028 @default.
• W2395641346 cites W2197777403 @default.
• W2395641346 cites W2615154296 @default.
• W2395641346 cites W4211052611 @default.
• W2395641346 doi "https://doi.org/10.1002/jcph.775" @default.
• W2395641346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5240044" @default.
• W2395641346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27225747" @default.
• W2395641346 hasPublicationYear "2016" @default.
• W2395641346 type Work @default.
• W2395641346 sameAs 2395641346 @default.
• W2395641346 citedByCount "34" @default.
• W2395641346 countsByYear W23956413462017 @default.
• W2395641346 countsByYear W23956413462018 @default.
• W2395641346 countsByYear W23956413462019 @default.
• W2395641346 countsByYear W23956413462020 @default.
• W2395641346 countsByYear W23956413462021 @default.
• W2395641346 countsByYear W23956413462022 @default.
• W2395641346 countsByYear W23956413462023 @default.
• W2395641346 crossrefType "journal-article" @default.
• W2395641346 hasAuthorship W2395641346A5035285777 @default.
• W2395641346 hasAuthorship W2395641346A5051509877 @default.
• W2395641346 hasAuthorship W2395641346A5065118732 @default.
• W2395641346 hasAuthorship W2395641346A5076419453 @default.
• W2395641346 hasAuthorship W2395641346A5076597174 @default.
• W2395641346 hasAuthorship W2395641346A5079478687 @default.
• W2395641346 hasBestOaLocation W23956413462 @default.
• W2395641346 hasConcept C112705442 @default.
• W2395641346 hasConcept C126322002 @default.
• W2395641346 hasConcept C139254425 @default.
• W2395641346 hasConcept C2776239304 @default.
• W2395641346 hasConcept C2777288759 @default.
• W2395641346 hasConcept C2777389121 @default.
• W2395641346 hasConcept C2777477808 @default.
• W2395641346 hasConcept C2908647359 @default.
• W2395641346 hasConcept C42219234 @default.
• W2395641346 hasConcept C71924100 @default.
• W2395641346 hasConcept C98274493 @default.
• W2395641346 hasConcept C99454951 @default.
• W2395641346 hasConceptScore W2395641346C112705442 @default.
• W2395641346 hasConceptScore W2395641346C126322002 @default.
• W2395641346 hasConceptScore W2395641346C139254425 @default.
• W2395641346 hasConceptScore W2395641346C2776239304 @default.
• W2395641346 hasConceptScore W2395641346C2777288759 @default.
• W2395641346 hasConceptScore W2395641346C2777389121 @default.
• W2395641346 hasConceptScore W2395641346C2777477808 @default.
• W2395641346 hasConceptScore W2395641346C2908647359 @default.
• W2395641346 hasConceptScore W2395641346C42219234 @default.

• next