Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395645431> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2395645431 endingPage "9" @default.
- W2395645431 startingPage "83" @default.
- W2395645431 abstract "Programmed cell death (apoptosis) is a process involved in the development of various tissues and suggested to be critical in the elimination of self-reactive immature T and B lymphocytes when they first encounter self antigens. To investigate further the role of apoptosis in the pathogenesis of autoimmune disease, the apoptotic phenomena of spleen cells and peritoneal cells of NZB/W F1 mice or nonautoimmune BALB/c mice were studied. Spleen cells and peritoneal cells were isolated and analyzed for their apoptotic phenomenon with the method of DNA staining. The data showed: 1) freshly isolated-spleen cells from BALB/c and NZB/W F1 mice showed little apoptosis as assessed by quantitative DNA flow cytometry, and had a significant increase with age (p < 0.001); 2) and data also showed that spleen cells of NZB/W F1 have higher spontaneous apoptotic rate than those of BALB/c mice (p < 0.05); 3) the apoptotic rate of dexamethasone (DEX)-treated spleen cells was lower in NZB/W F1 mice compared to that of nonautoimmune mice; 4) peritoneal cells showed little apoptosis when cells were freshly isolated and also had a striking increase with age (p < 0.05); 5) the apoptotic rate of DEX-treated peritoneal cells increased dramatically with age in BALB/c (p < 0.05), but not in NZB/W F1 mice. Our data showed quite clearly that splenic cells are much different from peritoneal cells according to their apoptotic responses. Furthermore, the apoptotic phenomenon of immune effector cells was also different between those of autoimmune and normal mice." @default.
- W2395645431 created "2016-06-24" @default.
- W2395645431 creator A5008596479 @default.
- W2395645431 creator A5009112038 @default.
- W2395645431 creator A5027785177 @default.
- W2395645431 creator A5068276761 @default.
- W2395645431 date "1999-06-01" @default.
- W2395645431 modified "2023-10-06" @default.
- W2395645431 title "Apoptotic phenomenon of immune effector cells in autoimmune NZB x NZW F1 mice." @default.
- W2395645431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11561580" @default.
- W2395645431 hasPublicationYear "1999" @default.
- W2395645431 type Work @default.
- W2395645431 sameAs 2395645431 @default.
- W2395645431 citedByCount "0" @default.
- W2395645431 crossrefType "journal-article" @default.
- W2395645431 hasAuthorship W2395645431A5008596479 @default.
- W2395645431 hasAuthorship W2395645431A5009112038 @default.
- W2395645431 hasAuthorship W2395645431A5027785177 @default.
- W2395645431 hasAuthorship W2395645431A5068276761 @default.
- W2395645431 hasConcept C147483822 @default.
- W2395645431 hasConcept C153911025 @default.
- W2395645431 hasConcept C190283241 @default.
- W2395645431 hasConcept C203014093 @default.
- W2395645431 hasConcept C2780130043 @default.
- W2395645431 hasConcept C2780931953 @default.
- W2395645431 hasConcept C553184892 @default.
- W2395645431 hasConcept C55493867 @default.
- W2395645431 hasConcept C86803240 @default.
- W2395645431 hasConcept C8891405 @default.
- W2395645431 hasConceptScore W2395645431C147483822 @default.
- W2395645431 hasConceptScore W2395645431C153911025 @default.
- W2395645431 hasConceptScore W2395645431C190283241 @default.
- W2395645431 hasConceptScore W2395645431C203014093 @default.
- W2395645431 hasConceptScore W2395645431C2780130043 @default.
- W2395645431 hasConceptScore W2395645431C2780931953 @default.
- W2395645431 hasConceptScore W2395645431C553184892 @default.
- W2395645431 hasConceptScore W2395645431C55493867 @default.
- W2395645431 hasConceptScore W2395645431C86803240 @default.
- W2395645431 hasConceptScore W2395645431C8891405 @default.
- W2395645431 hasIssue "2" @default.
- W2395645431 hasLocation W23956454311 @default.
- W2395645431 hasOpenAccess W2395645431 @default.
- W2395645431 hasPrimaryLocation W23956454311 @default.
- W2395645431 hasRelatedWork W1498654104 @default.
- W2395645431 hasRelatedWork W1979439339 @default.
- W2395645431 hasRelatedWork W2006557190 @default.
- W2395645431 hasRelatedWork W2035178547 @default.
- W2395645431 hasRelatedWork W2036107469 @default.
- W2395645431 hasRelatedWork W2081358646 @default.
- W2395645431 hasRelatedWork W2165321096 @default.
- W2395645431 hasRelatedWork W2215888429 @default.
- W2395645431 hasRelatedWork W2220102944 @default.
- W2395645431 hasRelatedWork W2376123765 @default.
- W2395645431 hasVolume "32" @default.
- W2395645431 isParatext "false" @default.
- W2395645431 isRetracted "false" @default.
- W2395645431 magId "2395645431" @default.
- W2395645431 workType "article" @default.