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- W2395672280 abstract "ABSTRACT The vertebrate GABAB receptor (GABABR) agonists 3-aminopropylphosphonous acid (3-APPA), SK&F97541 and 3-aminopropylphosphonic acid (3-APA) are able to induce a hyperpolarization on the cell body of motor neurone Df in the metathoracic ganglion of the cockroach (Periplaneta americana), although the classic vertebrate GABABR agonist L-baclofen fails to induce any responses on the same neurone. Consistent with the findings on vertebrate GABABRs, the 3-APPA-induced responses on Df were also insensitive to the GABAAR antagonists bicuculline and picrotoxin. However, the GABABR antagonists saclofen and CGP35348 also failed to block this GABAB-like response. These results indicate a novel pharmacology for the GABAB-like receptors on the Df neurone. The reversal potential indicates that these GABAB-like receptors may be coupled to K+ channels." @default.
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- W2395672280 date "1995-04-01" @default.
- W2395672280 modified "2023-10-18" @default.
- W2395672280 title "A GabaB Receptor on an Identified Insect Motor Neurone" @default.
- W2395672280 doi "https://doi.org/10.1242/jeb.198.4.889" @default.
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