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- W2395693024 abstract "Objectives：Expression of HMGI(Y), a nucleoprotein that binds to A/T rich sequences in the minor groove of the DNA helix, is observed in neoplastically transformed cells but not in normal cells. We have analyzed HMGI (Y) expression in the head and neck squamous cell carcinoma and evaluated its linicopathologic significance. Materials and Methods：HMGI(Y) mRNA was measured by RT-PCR and immunohistochemical staining for HMGI(Y) was performed in the head and neck squamous cell carcinoma. Results：Expression of HMGI(Y) by immunohistochemical staining was observed in 35 of 40 (87.5%) head and neck squamous cell carcinoma samples, whereas normal mucosa and/or the mucosa adjacent to the tumor tissue showed negative or weakly positive staining (p2.24 in cancer and 0.470.25 in normal tissue (p" @default.
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- W2395693024 date "2002-01-01" @default.
- W2395693024 modified "2023-09-23" @default.
- W2395693024 title "HMGI(Y) Protein Expression in Head and Neck Squamous Cell Carcinoma" @default.
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