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- W2395719466 abstract "There was considerable interest in the metabolism of oxalic acid by animals during the last half of the 19th century. Several years ago, it was observed that cats fed a commercial cat food developed oxalate nephrocalcinosis although there was no oxalate in their diet. Subsequent studies showed that because of the heat processing used in the preparation of the food, much of its vitamin B6 content had become biologically unavailable. This chapter reviews some of the work that ensued because of these two observations. Deposition of oxalate in the urinary tract is a serious concomitant of several pathologic conditions of man. A relationship between vitamin B6 deficiency and the endogenous production of oxalic acid has been observed in several animal species. Studies of the metabolism of oxalate precursors have raised new questions concerning the metabolism of a number of 2- and 3-carbon metabolites. It is now possible to produce in rat's urinary calcium oxalate calculi that are similar to those seen in man. Thus, a new approach has been provided for studying the effect of diet on the etiology of urinary stone formation." @default.
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- W2395719466 date "1964-01-01" @default.
- W2395719466 modified "2023-09-25" @default.
- W2395719466 title "Vitamin B6and Oxalate Metabolism" @default.
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- W2395719466 doi "https://doi.org/10.1016/s0083-6729(08)60353-2" @default.
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