FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395734408> ?p ?o ?g. }

• W2395734408 endingPage "e0155951" @default.
• W2395734408 startingPage "e0155951" @default.
• W2395734408 abstract "Adolescent alcohol use is the strongest predictor for alcohol use disorders. In rodents, adolescents have distinct responses to acute ethanol, and prolonged alcohol exposure during adolescence can maintain these phenotypes into adulthood. One brain region that is particularly sensitive to the effects of both acute and chronic ethanol exposure is the hippocampus. Adolescent intermittent ethanol exposure (AIE) produces long lasting changes in hippocampal synaptic plasticity and dendritic morphology, as well as in the susceptibility to acute ethanol-induced spatial memory impairment. Given the pattern of changes in hippocampal structure and function, one potential target for these effects is the ethanol sensitive GluN2B subunit of the NMDA receptor, which is known to be involved in synaptic plasticity and dendritic morphology. Thus we sought to determine if there were persistent changes in hippocampal GluN2B signaling cascades following AIE. We employed a previously validated GluN2B-targeted proteomic strategy that was used to identify novel signaling mechanisms altered by chronic ethanol exposure in the adult hippocampus. We collected adult hippocampal tissue (P70) from rats that had been given 2 weeks of AIE from P30-45. Tissue extracts were fractionated into synaptic and non-synaptic pools, immuno-precipitated for GluN2B, and then analyzed using proteomic methods. We detected a large number of proteins associated with GluN2B. AIE produced significant changes in the association of many proteins with GluN2B in both synaptic and non-synaptic fractions. Intriguingly the number of proteins changed in the non-synaptic fraction was double that found in the synaptic fraction. Some of these proteins include those involved in glutamate signaling cytoskeleton rearrangement, calcium signaling, and plasticity. Disruptions in these pathways may contribute to the persistent cellular and behavioral changes found in the adult hippocampus following AIE. Further, the robust change in non-synaptic proteins suggests that AIE may prime this signaling pathway for future ethanol exposures in adulthood." @default.
• W2395734408 created "2016-06-24" @default.
• W2395734408 creator A5016281292 @default.
• W2395734408 creator A5017483992 @default.
• W2395734408 creator A5037117974 @default.
• W2395734408 creator A5045487847 @default.
• W2395734408 creator A5058769699 @default.
• W2395734408 creator A5089809055 @default.
• W2395734408 date "2016-05-23" @default.
• W2395734408 modified "2023-10-16" @default.
• W2395734408 title "Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure" @default.
• W2395734408 cites W1810244153 @default.
• W2395734408 cites W1953313989 @default.
• W2395734408 cites W1966556202 @default.
• W2395734408 cites W1971330591 @default.
• W2395734408 cites W1976179462 @default.
• W2395734408 cites W1980260287 @default.
• W2395734408 cites W1983807711 @default.
• W2395734408 cites W1984956928 @default.
• W2395734408 cites W1997054612 @default.
• W2395734408 cites W1998973288 @default.
• W2395734408 cites W2008488411 @default.
• W2395734408 cites W2011448874 @default.
• W2395734408 cites W2016977783 @default.
• W2395734408 cites W2032681902 @default.
• W2395734408 cites W2034336478 @default.
• W2395734408 cites W2037852973 @default.
• W2395734408 cites W2042051919 @default.
• W2395734408 cites W2049614210 @default.
• W2395734408 cites W2049746655 @default.
• W2395734408 cites W2053373257 @default.
• W2395734408 cites W2058272715 @default.
• W2395734408 cites W2060375736 @default.
• W2395734408 cites W2069361702 @default.
• W2395734408 cites W2070601362 @default.
• W2395734408 cites W2076283597 @default.
• W2395734408 cites W2083911700 @default.
• W2395734408 cites W2085229989 @default.
• W2395734408 cites W2088753284 @default.
• W2395734408 cites W2091368956 @default.
• W2395734408 cites W2095285097 @default.
• W2395734408 cites W2095421975 @default.
• W2395734408 cites W2096640856 @default.
• W2395734408 cites W2116635659 @default.
• W2395734408 cites W2131727767 @default.
• W2395734408 cites W2136510368 @default.
• W2395734408 cites W2145265000 @default.
• W2395734408 cites W2146831587 @default.
• W2395734408 cites W2151791677 @default.
• W2395734408 cites W2155909540 @default.
• W2395734408 doi "https://doi.org/10.1371/journal.pone.0155951" @default.
• W2395734408 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4877005" @default.
• W2395734408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27213757" @default.
• W2395734408 hasPublicationYear "2016" @default.
• W2395734408 type Work @default.
• W2395734408 sameAs 2395734408 @default.
• W2395734408 citedByCount "26" @default.
• W2395734408 countsByYear W23957344082017 @default.
• W2395734408 countsByYear W23957344082018 @default.
• W2395734408 countsByYear W23957344082019 @default.
• W2395734408 countsByYear W23957344082020 @default.
• W2395734408 countsByYear W23957344082021 @default.
• W2395734408 countsByYear W23957344082022 @default.
• W2395734408 countsByYear W23957344082023 @default.
• W2395734408 crossrefType "journal-article" @default.
• W2395734408 hasAuthorship W2395734408A5016281292 @default.
• W2395734408 hasAuthorship W2395734408A5017483992 @default.
• W2395734408 hasAuthorship W2395734408A5037117974 @default.
• W2395734408 hasAuthorship W2395734408A5045487847 @default.
• W2395734408 hasAuthorship W2395734408A5058769699 @default.
• W2395734408 hasAuthorship W2395734408A5089809055 @default.
• W2395734408 hasBestOaLocation W23957344081 @default.
• W2395734408 hasConcept C104397665 @default.
• W2395734408 hasConcept C148762608 @default.
• W2395734408 hasConcept C169760540 @default.
• W2395734408 hasConcept C170493617 @default.
• W2395734408 hasConcept C185592680 @default.
• W2395734408 hasConcept C25274449 @default.
• W2395734408 hasConcept C2780161600 @default.
• W2395734408 hasConcept C2781161787 @default.
• W2395734408 hasConcept C55493867 @default.
• W2395734408 hasConcept C67018056 @default.
• W2395734408 hasConcept C86803240 @default.
• W2395734408 hasConcept C98229152 @default.
• W2395734408 hasConceptScore W2395734408C104397665 @default.
• W2395734408 hasConceptScore W2395734408C148762608 @default.
• W2395734408 hasConceptScore W2395734408C169760540 @default.
• W2395734408 hasConceptScore W2395734408C170493617 @default.
• W2395734408 hasConceptScore W2395734408C185592680 @default.
• W2395734408 hasConceptScore W2395734408C25274449 @default.
• W2395734408 hasConceptScore W2395734408C2780161600 @default.
• W2395734408 hasConceptScore W2395734408C2781161787 @default.
• W2395734408 hasConceptScore W2395734408C55493867 @default.
• W2395734408 hasConceptScore W2395734408C67018056 @default.
• W2395734408 hasConceptScore W2395734408C86803240 @default.
• W2395734408 hasConceptScore W2395734408C98229152 @default.
• W2395734408 hasFunder F4320306127 @default.
• W2395734408 hasFunder F4320337330 @default.

• next