Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395764503> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2395764503 endingPage "7" @default.
- W2395764503 startingPage "380" @default.
- W2395764503 abstract "Falciparum malaria may have infected Homo sapiens (and perhaps H erectus) in the Asia Pacific region for more than 100,000 years. This estimate is based on the gene frequency of alpha-thalassaemia, the protection it affords against falciparum malaria and assumptions of untreated mortality from the infection. Up until the end of the 19th century, there was a high mortality from malaria in the coastal parts of Malaya, but the malaria control campaign, begun in 1901 at Klang, was described by Sir Ronald Ross as the first successful antimalarial work in the (then) British Empire. This was extended to Singapore in 1911. When the Far Eastern Association of Tropical Medicine held its Fifth Biennial Congress in Singapore in 1923, malaria was still a major killing disease in parts of Malaya and Sarawak. The mechanism of life-threatening malaria involves cytoadherence of parasitised erythrocytes in microvascular beds, a process enhanced by the products of macrophage activation induced by malarial pyrogen. Improvements in the chemotherapy of life-threatening falciparum malaria with chloroquine and quinine have been countered by the emergence of resistant strains. Artemisinin derivatives may become the treatment of choice during the coming decade. Apart from traditional anti-mosquito methods, control of malaria now involves the use of insecticide-impregnated bed nets, new entomological strategies, including genetic manipulation of mosquitoes and selective chemoprophylaxis. Antigenic diversity and antigenic variation of the malaria parasite have so far defeated attempts to produce an effective vaccine." @default.
- W2395764503 created "2016-06-24" @default.
- W2395764503 creator A5070747216 @default.
- W2395764503 date "1997-05-01" @default.
- W2395764503 modified "2023-10-17" @default.
- W2395764503 title "The 1996 Runme Shaw Memorial Lecture: malaria--past, present and future." @default.
- W2395764503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9285035" @default.
- W2395764503 hasPublicationYear "1997" @default.
- W2395764503 type Work @default.
- W2395764503 sameAs 2395764503 @default.
- W2395764503 citedByCount "2" @default.
- W2395764503 crossrefType "journal-article" @default.
- W2395764503 hasAuthorship W2395764503A5070747216 @default.
- W2395764503 hasConcept C126322002 @default.
- W2395764503 hasConcept C136764020 @default.
- W2395764503 hasConcept C159047783 @default.
- W2395764503 hasConcept C203014093 @default.
- W2395764503 hasConcept C2776120307 @default.
- W2395764503 hasConcept C2776688490 @default.
- W2395764503 hasConcept C2777425658 @default.
- W2395764503 hasConcept C2777617192 @default.
- W2395764503 hasConcept C2778048844 @default.
- W2395764503 hasConcept C2778371730 @default.
- W2395764503 hasConcept C2778675580 @default.
- W2395764503 hasConcept C41008148 @default.
- W2395764503 hasConcept C71924100 @default.
- W2395764503 hasConcept C71928629 @default.
- W2395764503 hasConceptScore W2395764503C126322002 @default.
- W2395764503 hasConceptScore W2395764503C136764020 @default.
- W2395764503 hasConceptScore W2395764503C159047783 @default.
- W2395764503 hasConceptScore W2395764503C203014093 @default.
- W2395764503 hasConceptScore W2395764503C2776120307 @default.
- W2395764503 hasConceptScore W2395764503C2776688490 @default.
- W2395764503 hasConceptScore W2395764503C2777425658 @default.
- W2395764503 hasConceptScore W2395764503C2777617192 @default.
- W2395764503 hasConceptScore W2395764503C2778048844 @default.
- W2395764503 hasConceptScore W2395764503C2778371730 @default.
- W2395764503 hasConceptScore W2395764503C2778675580 @default.
- W2395764503 hasConceptScore W2395764503C41008148 @default.
- W2395764503 hasConceptScore W2395764503C71924100 @default.
- W2395764503 hasConceptScore W2395764503C71928629 @default.
- W2395764503 hasIssue "3" @default.
- W2395764503 hasLocation W23957645031 @default.
- W2395764503 hasOpenAccess W2395764503 @default.
- W2395764503 hasPrimaryLocation W23957645031 @default.
- W2395764503 hasRelatedWork W1592864042 @default.
- W2395764503 hasRelatedWork W2051072666 @default.
- W2395764503 hasRelatedWork W2071016885 @default.
- W2395764503 hasRelatedWork W2078857870 @default.
- W2395764503 hasRelatedWork W2095330432 @default.
- W2395764503 hasRelatedWork W2147993763 @default.
- W2395764503 hasRelatedWork W2169040557 @default.
- W2395764503 hasRelatedWork W2182039620 @default.
- W2395764503 hasRelatedWork W2290833602 @default.
- W2395764503 hasRelatedWork W76490652 @default.
- W2395764503 hasVolume "26" @default.
- W2395764503 isParatext "false" @default.
- W2395764503 isRetracted "false" @default.
- W2395764503 magId "2395764503" @default.
- W2395764503 workType "article" @default.