Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395845462> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2395845462 startingPage "141" @default.
- W2395845462 abstract "The role of proanthocyanidins (PC), a novel flavonoid extracted from grape seeds was studied in vitro in the modulation of neutrophil and macrophage function. We attempted to assess the levels of non-enzymatic and enzymatic mediators in the presence or absence of PC in 4-phorbol-12-beta-myristate-13-acetate (PMA)-stimulated neutrophils isolated from humans and rats, E. coli endotoxin-stimulated macrophages and macrophages isolated from E. coli endotoxin-induced experimental periodontitis in rats. Addition of PC at a concentration of 50 microg/ml effectively blocked the release of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and exhibited a marked inhibition of myeloperoxidase (MPO) and lysosomal enzymes (p<0.001), as compared to PMA-stimulated neutrophils (human and rats) and neutrophils isolated from experimental periodontitis in rats. The levels of ROS, RNS and lysosomal enzymes were found to be elevated (p<0.001) and addition of PC significantly (p<0.001) reduced these levels as compared to those from E. coli endotoxin-stimulatedmacrophages from rats and macrophages isolated from experimental periodontitis in rats (p<0.001). Thus, the study demonstrated that PC decreased the levels of ROS and RNS and also inhibited the MPO and lysosomal enzymes activities in experimental periodontitis in rats. In addition, this study clearly indicated that PC could be developed as an effective antiinflammatory agent." @default.
- W2395845462 created "2016-06-24" @default.
- W2395845462 creator A5044057231 @default.
- W2395845462 creator A5047316466 @default.
- W2395845462 creator A5085668120 @default.
- W2395845462 date "2010-06-01" @default.
- W2395845462 modified "2023-09-24" @default.
- W2395845462 title "In vitro studies on inhibitory effect of proanthocyanidins in modulation of neutrophils and macrophages." @default.
- W2395845462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20653284" @default.
- W2395845462 hasPublicationYear "2010" @default.
- W2395845462 type Work @default.
- W2395845462 sameAs 2395845462 @default.
- W2395845462 citedByCount "3" @default.
- W2395845462 countsByYear W23958454622015 @default.
- W2395845462 countsByYear W23958454622016 @default.
- W2395845462 crossrefType "journal-article" @default.
- W2395845462 hasAuthorship W2395845462A5044057231 @default.
- W2395845462 hasAuthorship W2395845462A5047316466 @default.
- W2395845462 hasAuthorship W2395845462A5085668120 @default.
- W2395845462 hasConcept C126322002 @default.
- W2395845462 hasConcept C153911025 @default.
- W2395845462 hasConcept C181199279 @default.
- W2395845462 hasConcept C185592680 @default.
- W2395845462 hasConcept C195794163 @default.
- W2395845462 hasConcept C202751555 @default.
- W2395845462 hasConcept C203014093 @default.
- W2395845462 hasConcept C203565725 @default.
- W2395845462 hasConcept C2776914184 @default.
- W2395845462 hasConcept C2778004101 @default.
- W2395845462 hasConcept C2779244956 @default.
- W2395845462 hasConcept C2780043322 @default.
- W2395845462 hasConcept C2780385504 @default.
- W2395845462 hasConcept C48349386 @default.
- W2395845462 hasConcept C55493867 @default.
- W2395845462 hasConcept C70899900 @default.
- W2395845462 hasConcept C71924100 @default.
- W2395845462 hasConcept C77784730 @default.
- W2395845462 hasConcept C86803240 @default.
- W2395845462 hasConcept C98274493 @default.
- W2395845462 hasConceptScore W2395845462C126322002 @default.
- W2395845462 hasConceptScore W2395845462C153911025 @default.
- W2395845462 hasConceptScore W2395845462C181199279 @default.
- W2395845462 hasConceptScore W2395845462C185592680 @default.
- W2395845462 hasConceptScore W2395845462C195794163 @default.
- W2395845462 hasConceptScore W2395845462C202751555 @default.
- W2395845462 hasConceptScore W2395845462C203014093 @default.
- W2395845462 hasConceptScore W2395845462C203565725 @default.
- W2395845462 hasConceptScore W2395845462C2776914184 @default.
- W2395845462 hasConceptScore W2395845462C2778004101 @default.
- W2395845462 hasConceptScore W2395845462C2779244956 @default.
- W2395845462 hasConceptScore W2395845462C2780043322 @default.
- W2395845462 hasConceptScore W2395845462C2780385504 @default.
- W2395845462 hasConceptScore W2395845462C48349386 @default.
- W2395845462 hasConceptScore W2395845462C55493867 @default.
- W2395845462 hasConceptScore W2395845462C70899900 @default.
- W2395845462 hasConceptScore W2395845462C71924100 @default.
- W2395845462 hasConceptScore W2395845462C77784730 @default.
- W2395845462 hasConceptScore W2395845462C86803240 @default.
- W2395845462 hasConceptScore W2395845462C98274493 @default.
- W2395845462 hasIssue "3" @default.
- W2395845462 hasLocation W23958454621 @default.
- W2395845462 hasLocation W23958454622 @default.
- W2395845462 hasOpenAccess W2395845462 @default.
- W2395845462 hasPrimaryLocation W23958454621 @default.
- W2395845462 hasRelatedWork W1514451801 @default.
- W2395845462 hasRelatedWork W1649797790 @default.
- W2395845462 hasRelatedWork W1730096292 @default.
- W2395845462 hasRelatedWork W1844363986 @default.
- W2395845462 hasRelatedWork W1969209289 @default.
- W2395845462 hasRelatedWork W1979413781 @default.
- W2395845462 hasRelatedWork W1991163901 @default.
- W2395845462 hasRelatedWork W1995291340 @default.
- W2395845462 hasRelatedWork W1997637601 @default.
- W2395845462 hasRelatedWork W2008737991 @default.
- W2395845462 hasRelatedWork W2017465006 @default.
- W2395845462 hasRelatedWork W2022899457 @default.
- W2395845462 hasRelatedWork W2046728089 @default.
- W2395845462 hasRelatedWork W2186746748 @default.
- W2395845462 hasRelatedWork W2432593342 @default.
- W2395845462 hasRelatedWork W2440229539 @default.
- W2395845462 hasRelatedWork W2885476067 @default.
- W2395845462 hasRelatedWork W2910131703 @default.
- W2395845462 hasRelatedWork W3043065223 @default.
- W2395845462 hasRelatedWork W3146166939 @default.
- W2395845462 hasVolume "47" @default.
- W2395845462 isParatext "false" @default.
- W2395845462 isRetracted "false" @default.
- W2395845462 magId "2395845462" @default.
- W2395845462 workType "article" @default.