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- W2395868489 abstract "In allografted rat lungs during acute rejection we studied mode of mononuclear cell infiltration histologically, and changes in the relative proportion of T cell subsets immunohistochemically. Orthotopic lung transplantations were performed in PT1-incompatible rat strains (n = 37). The transplanted rat lungs were examined using H-E staining and immunohistochemical staining with antirat-lymphocyte monoclonal antibody. Histological investigation showed the site of mononuclear cell infiltration shifted rapidly from larger vessels to smaller vessels, and finally to alveolar region within three days. Immunohistochemically, helper T cells were more abundant than cytotoxic-suppressor T cells until day 3. However, the ratio of helper to cytotoxic-suppressor T cells were reversed on day 4 when cytotoxic-suppressor T cells were most abundant. This rapid change in the proportion of T cell subsets has not been reported for other organ transplants. Why lung allografts are rejected more rapidly than other organs may be explained by the sudden change in T cell subsets together with the rapid shift in the site of cellular infiltration." @default.
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- W2395868489 date "1991-10-01" @default.
- W2395868489 modified "2023-10-18" @default.
- W2395868489 title "[Histological and immunohistological investigations of acute rejection of the allografted rat lung]." @default.
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