Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395874748> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2395874748 endingPage "99" @default.
- W2395874748 startingPage "83" @default.
- W2395874748 abstract "Heme oxygenase (HO) degrades heme to carbon monoxide (CO), ferrous ions, and the bile pigment biliverdin, which is subsequently reduced to the other important bile pigment, bilirubin, by biliverdin reductase. Fe2+ liberated from the heme molecule upregulates ferritin production, and bile pigments are potent endogenous antioxidants. The HO enzyme exists in three isophorms: HO-1 is expressed at low levels under physiological conditions, but is induced by numerous factors, including oxidative stress, inflammation, nitric oxide, an elevated level of substrate, and hypoxia. HO-2 is a constitutive enzyme involved in the baseline production of CO in the cardiovascular and nervous systems, whereas HO-3 is also ubiquitously expressed, but possesses low catalytic activity. Like nitric oxide, CO activates soluble guanylate cyclase and elevates cGMP in target tissues, which dilates blood vessels. It also does this by directly activating potassium channels in vascular smooth muscle cells. In addition, CO inhibits platelet aggregation and proliferation of vascular smooth muscle cells, inhibits apoptosis, and stimulates angiogenesis. Both deficiency, and excess of HO-1 may be involved in the pathogenesis of arterial hypertension. Induction of HO-1 attenuates atherosclerosis and myocardial ischemia-reperfusion injury. Pharmacological and genetic induction of HO-1 as well as the delivery of exogenous CO are promising therapeutic strategies for the treatment of cardiovascular diseases." @default.
- W2395874748 created "2016-06-24" @default.
- W2395874748 creator A5049277205 @default.
- W2395874748 creator A5058542360 @default.
- W2395874748 creator A5069767926 @default.
- W2395874748 date "2004-03-03" @default.
- W2395874748 modified "2023-09-23" @default.
- W2395874748 title "[Heme oxygenase and carbon monoxide in the physiology and pathology of the cardiovascular system]." @default.
- W2395874748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15069378" @default.
- W2395874748 hasPublicationYear "2004" @default.
- W2395874748 type Work @default.
- W2395874748 sameAs 2395874748 @default.
- W2395874748 citedByCount "8" @default.
- W2395874748 countsByYear W23958747482015 @default.
- W2395874748 countsByYear W23958747482016 @default.
- W2395874748 countsByYear W23958747482017 @default.
- W2395874748 crossrefType "journal-article" @default.
- W2395874748 hasAuthorship W2395874748A5049277205 @default.
- W2395874748 hasAuthorship W2395874748A5058542360 @default.
- W2395874748 hasAuthorship W2395874748A5069767926 @default.
- W2395874748 hasConcept C126322002 @default.
- W2395874748 hasConcept C134018914 @default.
- W2395874748 hasConcept C181199279 @default.
- W2395874748 hasConcept C185592680 @default.
- W2395874748 hasConcept C2776151105 @default.
- W2395874748 hasConcept C2776217839 @default.
- W2395874748 hasConcept C2776253728 @default.
- W2395874748 hasConcept C2777513400 @default.
- W2395874748 hasConcept C2779219270 @default.
- W2395874748 hasConcept C2779395532 @default.
- W2395874748 hasConcept C2992686903 @default.
- W2395874748 hasConcept C519581460 @default.
- W2395874748 hasConcept C55493867 @default.
- W2395874748 hasConcept C71924100 @default.
- W2395874748 hasConcept C86803240 @default.
- W2395874748 hasConcept C98274493 @default.
- W2395874748 hasConceptScore W2395874748C126322002 @default.
- W2395874748 hasConceptScore W2395874748C134018914 @default.
- W2395874748 hasConceptScore W2395874748C181199279 @default.
- W2395874748 hasConceptScore W2395874748C185592680 @default.
- W2395874748 hasConceptScore W2395874748C2776151105 @default.
- W2395874748 hasConceptScore W2395874748C2776217839 @default.
- W2395874748 hasConceptScore W2395874748C2776253728 @default.
- W2395874748 hasConceptScore W2395874748C2777513400 @default.
- W2395874748 hasConceptScore W2395874748C2779219270 @default.
- W2395874748 hasConceptScore W2395874748C2779395532 @default.
- W2395874748 hasConceptScore W2395874748C2992686903 @default.
- W2395874748 hasConceptScore W2395874748C519581460 @default.
- W2395874748 hasConceptScore W2395874748C55493867 @default.
- W2395874748 hasConceptScore W2395874748C71924100 @default.
- W2395874748 hasConceptScore W2395874748C86803240 @default.
- W2395874748 hasConceptScore W2395874748C98274493 @default.
- W2395874748 hasLocation W23958747481 @default.
- W2395874748 hasOpenAccess W2395874748 @default.
- W2395874748 hasPrimaryLocation W23958747481 @default.
- W2395874748 hasRelatedWork W112787558 @default.
- W2395874748 hasRelatedWork W1263203087 @default.
- W2395874748 hasRelatedWork W136319983 @default.
- W2395874748 hasRelatedWork W1995315566 @default.
- W2395874748 hasRelatedWork W1996805006 @default.
- W2395874748 hasRelatedWork W200418031 @default.
- W2395874748 hasRelatedWork W2037123879 @default.
- W2395874748 hasRelatedWork W2054998714 @default.
- W2395874748 hasRelatedWork W2070061643 @default.
- W2395874748 hasRelatedWork W2102764780 @default.
- W2395874748 hasRelatedWork W2105509107 @default.
- W2395874748 hasRelatedWork W2155519253 @default.
- W2395874748 hasRelatedWork W2367367781 @default.
- W2395874748 hasRelatedWork W2388532346 @default.
- W2395874748 hasRelatedWork W2399218898 @default.
- W2395874748 hasRelatedWork W2527424372 @default.
- W2395874748 hasRelatedWork W50853749 @default.
- W2395874748 hasRelatedWork W657812613 @default.
- W2395874748 hasRelatedWork W69371081 @default.
- W2395874748 hasRelatedWork W94520563 @default.
- W2395874748 hasVolume "58" @default.
- W2395874748 isParatext "false" @default.
- W2395874748 isRetracted "false" @default.
- W2395874748 magId "2395874748" @default.
- W2395874748 workType "article" @default.