Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395937951> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2395937951 endingPage "355" @default.
- W2395937951 startingPage "349" @default.
- W2395937951 abstract "Objective To observe the inhibitive effect of pirenzepine on form deprivation myopia in guinea pigs and to explore the mechanism of Smad3 signaling pathway and connective tissue growth factor(CTGF)in the inhibition of myopia by pirenzepine.Methods Forty 1-week-old guinea pigs of either sex were randomly divided into 4 groups:a control group(Group Ⅰ),a form deprivation group(Group Ⅱ),a pirenzepine ophthalmic solution group(Group Ⅲ),and a sodium chloride ophthalmic solution group(Group Ⅳ).Translucent blinders were used in the right eyes of Group Ⅱ,Ⅲ and Ⅳ.The left eyes were not given any treatment as the normal control group.Covered eyes of Group Ⅲ and Ⅳ were given 3% pirenzepine ophthalmic solution and 0.1% azone ophthalmic solution respectively twice every day.Six weeks later,refraction and axial length were measured at the end of the experiment,and immunohistochemistry and Western blot were used to analyze the expression levels of Smad3 and CTGF in the sclera of all 4 groups.Results There was no signi-ficant difference between Group ⅢandⅠin relative refraction and changes of axial length(P0.05).The difference of GroupⅡ and Ⅳ compared with GroupⅠwas statistically significant(P0.05).The number of Smad3 and CTGF positive cells in the sclera between GroupⅢandⅠwas not significantly different(P0.05),while the difference in GroupⅡ,ⅣandⅠwas significant(P0.05).Western blot showed that the expression levels of Smad3 and CTGF in GroupⅡand Ⅳ were much lower than those in GroupⅠ(P0.05),but not evident in Group Ⅲ andⅠ(P0.05).Conclusion Pirenzepine ophthalmic solution can inhibit the development of form deprivation myopia.Pirenzepine may affect Smad3 signaling pathway in the sclera by inhibiting the development of form deprivation myopia." @default.
- W2395937951 created "2016-06-24" @default.
- W2395937951 creator A5002167365 @default.
- W2395937951 creator A5032423839 @default.
- W2395937951 creator A5033115045 @default.
- W2395937951 creator A5067192459 @default.
- W2395937951 creator A5084590705 @default.
- W2395937951 date "2009-04-01" @default.
- W2395937951 modified "2023-09-28" @default.
- W2395937951 title "Mechanism of Smad 3 signaling pathway and connective tissue growth factor in the inhibition of form deprivation myopia by pirenzepine" @default.
- W2395937951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19411755" @default.
- W2395937951 hasPublicationYear "2009" @default.
- W2395937951 type Work @default.
- W2395937951 sameAs 2395937951 @default.
- W2395937951 citedByCount "3" @default.
- W2395937951 countsByYear W23959379512016 @default.
- W2395937951 countsByYear W23959379512017 @default.
- W2395937951 crossrefType "journal-article" @default.
- W2395937951 hasAuthorship W2395937951A5002167365 @default.
- W2395937951 hasAuthorship W2395937951A5032423839 @default.
- W2395937951 hasAuthorship W2395937951A5033115045 @default.
- W2395937951 hasAuthorship W2395937951A5067192459 @default.
- W2395937951 hasAuthorship W2395937951A5084590705 @default.
- W2395937951 hasConcept C104317684 @default.
- W2395937951 hasConcept C118487528 @default.
- W2395937951 hasConcept C126322002 @default.
- W2395937951 hasConcept C134018914 @default.
- W2395937951 hasConcept C142724271 @default.
- W2395937951 hasConcept C170493617 @default.
- W2395937951 hasConcept C185592680 @default.
- W2395937951 hasConcept C2775960820 @default.
- W2395937951 hasConcept C2776415932 @default.
- W2395937951 hasConcept C2776885963 @default.
- W2395937951 hasConcept C2777100477 @default.
- W2395937951 hasConcept C2778616617 @default.
- W2395937951 hasConcept C2780631158 @default.
- W2395937951 hasConcept C518705261 @default.
- W2395937951 hasConcept C55493867 @default.
- W2395937951 hasConcept C71924100 @default.
- W2395937951 hasConceptScore W2395937951C104317684 @default.
- W2395937951 hasConceptScore W2395937951C118487528 @default.
- W2395937951 hasConceptScore W2395937951C126322002 @default.
- W2395937951 hasConceptScore W2395937951C134018914 @default.
- W2395937951 hasConceptScore W2395937951C142724271 @default.
- W2395937951 hasConceptScore W2395937951C170493617 @default.
- W2395937951 hasConceptScore W2395937951C185592680 @default.
- W2395937951 hasConceptScore W2395937951C2775960820 @default.
- W2395937951 hasConceptScore W2395937951C2776415932 @default.
- W2395937951 hasConceptScore W2395937951C2776885963 @default.
- W2395937951 hasConceptScore W2395937951C2777100477 @default.
- W2395937951 hasConceptScore W2395937951C2778616617 @default.
- W2395937951 hasConceptScore W2395937951C2780631158 @default.
- W2395937951 hasConceptScore W2395937951C518705261 @default.
- W2395937951 hasConceptScore W2395937951C55493867 @default.
- W2395937951 hasConceptScore W2395937951C71924100 @default.
- W2395937951 hasIssue "4" @default.
- W2395937951 hasLocation W23959379511 @default.
- W2395937951 hasLocation W23959379512 @default.
- W2395937951 hasOpenAccess W2395937951 @default.
- W2395937951 hasPrimaryLocation W23959379511 @default.
- W2395937951 hasRelatedWork W2338206473 @default.
- W2395937951 hasRelatedWork W2350930443 @default.
- W2395937951 hasRelatedWork W2354972793 @default.
- W2395937951 hasRelatedWork W2356201749 @default.
- W2395937951 hasRelatedWork W2362356233 @default.
- W2395937951 hasRelatedWork W2365735840 @default.
- W2395937951 hasRelatedWork W2367475876 @default.
- W2395937951 hasRelatedWork W2368738904 @default.
- W2395937951 hasRelatedWork W2369835160 @default.
- W2395937951 hasRelatedWork W2374821624 @default.
- W2395937951 hasRelatedWork W2382948204 @default.
- W2395937951 hasRelatedWork W2391040409 @default.
- W2395937951 hasRelatedWork W2391264072 @default.
- W2395937951 hasRelatedWork W2393190292 @default.
- W2395937951 hasRelatedWork W2397834211 @default.
- W2395937951 hasRelatedWork W2411656456 @default.
- W2395937951 hasRelatedWork W2423884529 @default.
- W2395937951 hasRelatedWork W3030366583 @default.
- W2395937951 hasRelatedWork W3031403285 @default.
- W2395937951 hasRelatedWork W3031982795 @default.
- W2395937951 hasVolume "34" @default.
- W2395937951 isParatext "false" @default.
- W2395937951 isRetracted "false" @default.
- W2395937951 magId "2395937951" @default.
- W2395937951 workType "article" @default.