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• W2395978789 abstract "Although intron losses have been widely reported, it is not clear whether they are neutral and therefore random or driven by positive selection. Intron transcription and splicing are time-consuming and can delay the expression of its host gene. For genes that must be activated quickly to respond to physiological or stress signals, intron delay may be deleterious. Promoter proximally paused (PPP) genes are a group of rapidly expressed genes. To respond quickly to activation signals, they generally initiate transcription competently but stall after synthesizing a short RNA. In this study, performed in Drosophila melanogaster, the PPP genes were found to have a significantly higher rate of intron loss than control genes. However, further analysis did not find more significant shrinkage of intron size in PPP genes. Referring to previous studies on the rates of transcription and splicing and to the time saved by deletion of the introns from mouse gene Hes7, it is here suggested that transcription delay is comparable to splicing delay only when the intron is 28.5 kb or larger, which is greater in size than 95% of vertebrate introns, 99.5% of Drosophila introns, and all the annotated introns of Saccharomyces cerevisiae and Arabidopsis thaliana. Delays in intron splicing are probably a selective force, promoting intron loss from quickly expressed genes. In other genes, it may have been an exaptation during the emergency of developmental clocks." @default.
• W2395978789 created "2016-06-24" @default.
• W2395978789 creator A5026010256 @default.
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• W2395978789 date "2014-04-04" @default.
• W2395978789 modified "2023-09-27" @default.
• W2395978789 title "Higher frequency of intron loss from the promoter proximally paused genes ofDrosophila melanogaster" @default.
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• W2395978789 doi "https://doi.org/10.4161/fly.29489" @default.
• W2395978789 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4197015" @default.
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• W2395978789 hasPublicationYear "2014" @default.
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