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- W2396001954 abstract "In 34 cases of cancers of the urogenital tract such as the bladder, the prostate, and the kidneys, the total hemolytic complement (CH50), the proteins of the complement-system (C1q, C15, C4, C3, C5, C9, C3a and C3-A) and the proteinase inhibitors (C1s-INH, AT-III, α1-AT and α2-M) in the serum were measured.Our results are summarized in the following. 1) Among the proteins of the complement-system, C9 was found to be remarkably elevated in the cases of cancer in the urogenital tract, and its elevation became more predominant as the stage of the illness progressed. 2) C1s-INH showed a significant increase along with the progression of cancer. The presence of a close correlationship between C1s-INH and C4 was documented. 3) C3-A also demonstrated a tendency to increase as the stage of cancer progressed. A close correlationship between C3-A and C3a was observed. 4) AT-III, which showed a generalized tendency to decrease in the cases of cancer, demonstrated a marked decrease in the cases of cancer of the prostate. 5) α1-AT showed a tendency to increase in all cases and α2-M showed the same tendency only in male cases of cancer.From these studies, it is concluded that the presence of a generalized increase of the complement-system in the serum of the cases of cancer in the urogenital tract is confirmed and these findings should be considered pathophysiologically in close association with previously well-documented findings of a decrease of fibrinolytic activity and an increased activation of coagulation system in the blood in the cases of cancer, and it is also speculated that these changes might possibly be supplying a favorable environment for the progression of cancer." @default.
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- W2396001954 date "1978-01-01" @default.
- W2396001954 modified "2023-10-01" @default.
- W2396001954 title "DYSPROTEINEMIA IN MALIGNANT TUMORS OF THE UROGENITAL SYSTEM" @default.
- W2396001954 doi "https://doi.org/10.5980/jpnjurol1928.69.3_365" @default.
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