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- W2396006943 abstract "The physiological availability of chlorpromazine administered as three oral preparations (tablets, liquid, and long-acting capsules) and by intramuscular iniection was measured in 13 psychiatric patients under steady-state conditions and 8 previously untreated sub;ects given single doses. Determinations of plasma levels of chlorpromazine, as well as urinary excretion of con;ugated and uncon;ugated metabolites, were used as the criteria of physiological availability. Under each condition, the availability of drug followed the same order in regard to the oral preparations: liquid, tablets, and long-acting capsules. Differences were far more apparent in plasma levels than in urinary excretion. None of the oral dosage forms was completely reliable, but in steady-state conditions, all tended to produce sustained plasma levels. On the other hand, intramuscular injection of drug, even in doses approximating one third of the same oral dose, led to rapid and regular appearance of significant plasma levels of drug and a consistently higher per cent of the administered dose in the urine. The use of the long-acting oral dosage form does not seem warranted for a drug such as chlorpromazine; liquid or tablet dosage forms were more reliable and satisfied the claims made for long-acting dosage forms in chronic treatment." @default.
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- W2396006943 date "1970-01-01" @default.
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- W2396006943 title "Studies of delayed-action medication V. Plasma levels and urinary excretion of four different dosage forms of chlorpromazine" @default.
- W2396006943 doi "https://doi.org/10.1002/cpt197011149" @default.
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