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• W2396007554 abstract "The search for intermediate phenotypes to inform genetic studies of psychiatric disorders is never as productive and exciting as in neuropsychological studies, particularly those of schizophrenia. A variety of cognitive impairments are frequently seen in patients with schizophrenia, and appear to be core features of this illness. In contrast, cognitive impairments seen in other psychiatric disorders, such as depression and mania, are state-related and may not be essential to these disorders (). In studies of patients with schizophrenia, cognitive impairments do not appear to be caused simply by secondary factors associated with severe mental illness, such as poor cooperation or medications. They are present from an early stage of the illness and are stable over time, suggesting trait-like properties. Furthermore, emerging data suggest, but have not proven, that different profiles of impairment may be present in subgroups of patients. Another feature that makes these cognitive measures attractive targets for genetic studies is that they are closely related to clinical and functional outcome. Thus, the genes underlying cognitive phenotypes may be the most relevant to improving the quality of patients’ lives. Three domains of cognition are generally affected, including working memory/executive function, verbal/declarative memory, and attention." @default.
• W2396007554 created "2016-06-24" @default.
• W2396007554 creator A5053074980 @default.
• W2396007554 creator A5068879555 @default.
• W2396007554 date "2003-11-14" @default.
• W2396007554 modified "2023-10-18" @default.
• W2396007554 title "Intermediate Cognitive Phenotypes Associated with Schizophrenia" @default.
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• W2396007554 doi "https://doi.org/10.1385/1-59259-348-8:163" @default.
• W2396007554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12298369" @default.
• W2396007554 hasPublicationYear "2003" @default.
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