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• W2396009852 abstract "Abstract We present non-faradaic electrochemical recordings of exocytosis from populations of mast and chromaffin cells using chemoreceptive neuron MOS (CνMOS) transistors. In comparison to previous cell-FET-biosensors, the CνMOS features control (CG), sensing (SG) and floating gates (FG), allows the quiescent point to be independently controlled, is CMOS compatible and physically isolates the transistor channel from the electrolyte for stable long-term recordings. We measured exocytosis from RBL-2H3 mast cells sensitized by IgE (bound to high-affinity surface receptors FcεRI) and stimulated using the antigen DNP-BSA. Quasi-static I-V measurements reflected a slow shift in surface potential (Equation missing<!-- image only, no MathML or LaTex -->) which was dependent on extracellular calcium ([Ca] o ) and buffer strength, which suggests sensitivity to protons released during exocytosis. Fluorescent imaging of dextran-labeled vesicle release showed evidence of a similar time course, while un-sensitized cells showed no response to stimulation. Transient recordings revealed Equation missing<!-- image only, no MathML or LaTex --> fluctuations with a rapid rise and slow decay. Chromaffin cells stimulated with high KCl showed both slow Equation missing<!-- image only, no MathML or LaTex --> shifts and extracellular action potentials exhibiting biphasic and inverted capacitive waveforms, indicative of varying ion-channel distributions across the cell-transistor junction. Our approach presents a facile method to simultaneously monitor exocytosis and ion channel activity with high temporal sensitivity without the need for redox chemistry." @default.
• W2396009852 created "2016-06-24" @default.
• W2396009852 creator A5002939449 @default.
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• W2396009852 date "2015-12-21" @default.
• W2396009852 modified "2023-09-27" @default.
• W2396009852 title "Non-Faradaic Electrochemical Detection of Exocytosis from Mast and Chromaffin Cells Using Floating-Gate MOS Transistors" @default.
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• W2396009852 doi "https://doi.org/10.1038/srep18477" @default.
• W2396009852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4685269" @default.
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• W2396009852 hasPublicationYear "2015" @default.
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