Matches in SemOpenAlex for { <https://semopenalex.org/work/W239602655> ?p ?o ?g. }
- W239602655 abstract "This chapter discusses skin cancer, more specifically melanoma, summarizing the factors that are most likely to cause onset of the disease, such as UV radiation in fair-skinned people, with all its stages and characteristics. Genetic alterations such as sporadic and heritable mutations are first described, followed by epigenetic aberrations, which are addressed in more detail. Global hypomethylation and site-specific DNA hypermethylation at certain gene promoters as well as the CpG methylator phenotype and histone posttranslational modifications are described. Further, polycomb group protein targets and microRNAs are explained along with their mechanism of action in silencing or upregulating the expression of those genes playing important roles in melanoma onset and progression. Finally, epigenetic therapies are discussed that, in turn, focus on drugs specifically counteracting aberrant DNA methylation patterns. The use of histone deacetylase inhibitors is also addressed." @default.
- W239602655 created "2016-06-24" @default.
- W239602655 creator A5036485404 @default.
- W239602655 creator A5076293102 @default.
- W239602655 date "2015-01-01" @default.
- W239602655 modified "2023-10-17" @default.
- W239602655 title "Epigenetics of Melanoma" @default.
- W239602655 cites W1712387145 @default.
- W239602655 cites W1964456085 @default.
- W239602655 cites W1966485273 @default.
- W239602655 cites W1970753913 @default.
- W239602655 cites W1974885520 @default.
- W239602655 cites W1979320437 @default.
- W239602655 cites W1981283223 @default.
- W239602655 cites W1981840233 @default.
- W239602655 cites W1983179216 @default.
- W239602655 cites W1983751803 @default.
- W239602655 cites W1984710781 @default.
- W239602655 cites W1985594917 @default.
- W239602655 cites W1985965203 @default.
- W239602655 cites W1986682099 @default.
- W239602655 cites W1992004236 @default.
- W239602655 cites W1998107133 @default.
- W239602655 cites W2003215649 @default.
- W239602655 cites W2003633088 @default.
- W239602655 cites W2004722288 @default.
- W239602655 cites W2006087233 @default.
- W239602655 cites W2007255413 @default.
- W239602655 cites W2008954479 @default.
- W239602655 cites W2009697023 @default.
- W239602655 cites W2010145752 @default.
- W239602655 cites W2010684135 @default.
- W239602655 cites W2014550839 @default.
- W239602655 cites W2014946489 @default.
- W239602655 cites W2017130328 @default.
- W239602655 cites W2018308631 @default.
- W239602655 cites W2018312373 @default.
- W239602655 cites W2025126134 @default.
- W239602655 cites W2025982955 @default.
- W239602655 cites W2026828840 @default.
- W239602655 cites W2028994134 @default.
- W239602655 cites W2033902109 @default.
- W239602655 cites W2040421463 @default.
- W239602655 cites W2040944433 @default.
- W239602655 cites W2042295867 @default.
- W239602655 cites W2045627244 @default.
- W239602655 cites W2045937114 @default.
- W239602655 cites W2046299975 @default.
- W239602655 cites W2047901982 @default.
- W239602655 cites W2050453705 @default.
- W239602655 cites W2050593870 @default.
- W239602655 cites W2051149841 @default.
- W239602655 cites W2051506850 @default.
- W239602655 cites W2054900304 @default.
- W239602655 cites W2055327476 @default.
- W239602655 cites W2057065967 @default.
- W239602655 cites W2057113047 @default.
- W239602655 cites W2057929910 @default.
- W239602655 cites W2060573548 @default.
- W239602655 cites W2060662007 @default.
- W239602655 cites W2063739042 @default.
- W239602655 cites W2064641360 @default.
- W239602655 cites W2066264051 @default.
- W239602655 cites W2070089404 @default.
- W239602655 cites W2072608354 @default.
- W239602655 cites W2072630073 @default.
- W239602655 cites W2080323885 @default.
- W239602655 cites W2082971158 @default.
- W239602655 cites W2083988824 @default.
- W239602655 cites W2084714894 @default.
- W239602655 cites W2085175510 @default.
- W239602655 cites W2086730810 @default.
- W239602655 cites W2086857599 @default.
- W239602655 cites W2086922349 @default.
- W239602655 cites W2087791044 @default.
- W239602655 cites W2088300416 @default.
- W239602655 cites W2089189552 @default.
- W239602655 cites W2090381051 @default.
- W239602655 cites W2090387552 @default.
- W239602655 cites W2092293354 @default.
- W239602655 cites W2094615311 @default.
- W239602655 cites W2095112712 @default.
- W239602655 cites W2095671229 @default.
- W239602655 cites W2096953854 @default.
- W239602655 cites W2097587005 @default.
- W239602655 cites W2099200814 @default.
- W239602655 cites W2099803844 @default.
- W239602655 cites W2100632164 @default.
- W239602655 cites W2101775966 @default.
- W239602655 cites W2106598032 @default.
- W239602655 cites W2107076128 @default.
- W239602655 cites W2108281054 @default.
- W239602655 cites W2108691372 @default.
- W239602655 cites W2109069210 @default.
- W239602655 cites W2111862114 @default.
- W239602655 cites W2114954124 @default.
- W239602655 cites W2114980132 @default.
- W239602655 cites W2116993454 @default.
- W239602655 cites W2117261377 @default.
- W239602655 cites W2118033225 @default.