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- W2396051708 abstract "tistically analyzed for significance. RESULTS: Median age at diagnosis was 53 years. With a median follow-up of 46.5 months, there was an 88% overall survival rate. Thirty-seven percent of the patients (p 0.001) were at stages III and IV during diagnosis. The hormone receptor human epidermal receptor negative phenotype ( HR-HER2-) (p 0.001) was present in 17% of the cases. In a multivariate analysis, local (risk ratio, RR: 7.2; confidence interval, CI 95%: 3.8–7.6; p = 0.06) and distant recurrence (RR: 14.9; CI 95%: 7.7–28.9; p = 0.01) showed the strongest association with the probability of death from the disease. Patients with HR-HER2- phenotype tumors reported more local recurrences (p = 0.04), a higher tumor grade (p 0.01), and lower overall survival than patients with other breast cancer phenotypes (p = 0.01). CONCLUSIONS: Although this study analyzes a modest number of cases, it is an initial insight into factors that may contribute to differences in breast cancer outcomes among Hispanic women in Costa Rica. The higher proportion of triple negative tumors, advanced stage, and younger median age at diag nosis could contribute to the inferior prognostic described among Hispanic women. There may be a different distribution of tumor subtypes compared to non-Hispanic white women. Further studies are necessary to confirm such findings." @default.
- W2396051708 created "2016-06-24" @default.
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- W2396051708 date "2016-11-29" @default.
- W2396051708 modified "2023-09-24" @default.
- W2396051708 title "Breast Cancer: Basic and Clinical Research" @default.
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- W2396051708 doi "https://doi.org/10.4137/bcbcr" @default.
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