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- W2396071169 abstract "Epithelial glycoprotein-1 (EGP-1, also known as TROP2) is a transmembrane glycoprotein (46 kDa) identified with murine IgG1 monoclonal antibody (mAb) RS7 raised against human non-small cell lung carcinoma (1). EGP-1 is also present in human carcinomas of the stomach, bladder, breast, ovary, uterus, and prostate, but it is not expressed in most normal tissues. EGP-1 is expressed at low levels in glandular cells in the bronchus, breast, prostate, skin, and pancreas. EGP-1 activates intracellular calcium mobilization (2) and protein kinase C (3) after binding with RS7. EGP-1 is a cell-surface receptor with unknown physiological ligand and cellular functions. However, EGP-1 has been implicated in the activation of the ERK/MAPK pathway, leading to downstream alterations in cellular proliferation, migration, invasion, and survival of cancer cells (4). EGP-1 overexpression has been associated with increased tumor invasiveness and decreased overall survival rates in multiple types of human carcinomas (5, 6). van Rij et al. (7) evaluated 111In-diethylenetriamine pentaacetic acid-hRS7 (111In-DTPA-hRS7) as a 111In-based single-photon emission computed tomography (SPECT) agent in human prostate PC-3 tumors in nude mice." @default.
- W2396071169 created "2016-06-24" @default.
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- W2396071169 date "2012-04-19" @default.
- W2396071169 modified "2023-09-23" @default.
- W2396071169 title "111In-Diethylenetriamine pentaacetic acid-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody" @default.
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