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- W2396097747 abstract "This study was conducted to investigate the mechanism of protective effect by sodium selenite in methylmercuric chloride neurotoxicity, increasing intracellular concentration of the neuron. Methylmercuric chloride of 3mg/kg of body weight was administered simultaneously with sodium selenite of 5mg/kg and pretreatment of sodium selenite via intraperitoneal injection to rats. Also, effect of methylmercuric chloride() and sodium selenite() on free intrasynaptosomal concentration were studied using the fluorescent indicator fura -2 in vitro. After the treatment, at 6, 24, and 48 hours later, mercury in the cerebral cortex, liver and kidney tissues, succlnic dehydrogenase activities, adenosin-5'-triphosphate concentration, acetylcholinesterase activities, and intracellular concentration in the cerebral cortex were determined in vivo. Cerebral synaptosomes of rats were incubated with methylmercuric chloride and sodium selenite in Hepes buffer for 10 minutes and free intrasynaptosomal concentration were measured with fura-2 in vitro. The results were summarized as follows ; 1. The combined administration of and and pretreatment of according to time significantly more increased in the cerebral cortex and decreased in the liver, kidney mercury concentrations compared to the administration of only. 2. The combined administration of and and pretreatment of increased more succinic dehydrogenase and acetylcholinesterase activities compared to the administration of only. Particularly pretreatment of significantly more compared to the administration of only. The concentration of adenosine-5'-triphosphate in treatment groups revealed a favourable effect compared to the administration of only. 3. Intracellular concentration in administration of only was increased significantly more than control group in all test hours but was increased significantly more at 48 hours only after treatment in combined administration of and and pretreatment of according to time interval more decreased significantly intracellular concentration compared to the administration of only. 4. Free intrasynaptosomal concentration in the combined administration of and was decreased () significantly more than the administration of only. From the above results, the specific dosage of decreased increment of intracellular concentration induced by administration of . These findings suggest the protective mechanism of on the neurotoxicity of ." @default.
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- W2396097747 date "1992-01-01" @default.
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- W2396097747 title "Interaction of Sodium Selenite on Neurotoxicity Induced by Methylmercuric Chloride" @default.
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