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- W2396108315 abstract "To evaluate the usefulness of the measurement of midnight salivary cortisol (SC) in the initial diagnosis of Cushing's syndrome (CS).A total of 18 patients with pathologically confirmed CS were recruited in the study. Thirteen patients with pure obesity and 36 healthy people served as controls. Salivary samples at 8:00, 16:00, 24:00 and 8:00 the next day after the 1 mg dexamethasone suppression test(DST) were collected by a commercially-available saliva collection device, and assayed by Electro Chemiluminescence Immuno Assay (ECLIA).There were highly significant correlations between salivary cortisol and plasma cortisol (PTC) at the 4 time points. The correlation coefficient was 0.73 (0.71, 0.74, 0.78 and 0.61 at the four time points, respectively) (P < 0.05). Midnight salivary cortisol level in Cushing's Syndrome [(10.58 +/- 5.17) nmol/L] was significantly higher than healthy people [(1.55 +/- 0.60) nmol/L]. The receiver operating characteristics curve (ROC) analysis showed a sensitivity of 100.00% and specificity of 84.00% at 8:00 with the cut-off point of 6.21 nmol/L.The measurement of midnight salivary cortisol is a convenience and noninvasive screening test for the initial diagnosis of Cushing's Syndrome." @default.
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- W2396108315 date "2009-03-01" @default.
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- W2396108315 title "[Diagnostic value of salivary cortisol in Cushing's syndrome]." @default.
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