FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396181853> ?p ?o ?g. }

• W2396181853 endingPage "1981" @default.
• W2396181853 startingPage "1977" @default.
• W2396181853 abstract "Abstract Natural killer (NK) cells are CD3− large granular lymphocytes (LGL) responsible for immunity against viral infections. A chronic lymphoproliferative disorder of NK cells has been described in which the expanded NK cells display a restricted phenotype and cytotoxic activity. These data raise the hypothesis that proliferating LGL in these patients result from discrete expansions of NK cells responding to an unknown, perhaps viral, antigen. Recently, it was found that mice transgenic for the tax gene of human T-cell leukemia/lymphoma virus (HTLV) develop NK leukemia. Therefore, we studied 15 patients with chronic NK lymphoproliferative disorder for evidence of HTLV infection. Sera were tested using an HTLV-I/II-enzyme linked immunosorbent assay and a modified Western blot assay containing recombinant env proteins. None of the sera met conventional criteria for HTLV seroreactivity. However, sera from 11 patients (73%) reacted with the recombinant HTLV env protein p21E. The anti-p21E reactivity of these sera was then mapped employing the recombinant proteins GD21 and BA21. No reactivity to the immunodominant HTLV epitope GD21 was observed, suggesting that prototypical HTLV infection is unlikely in these patients. This was confirmed by finding no evidence for HTLV nucleic acids by PCR analyses employing primers specific for conserved regions in the env, pol, and pX genes. In contrast, 10 of the 15 sera reacted with the epitope BA21, documenting for the first time an association between a unique seroreactivity and disease. The high incidence of BA21 seroreactivity in these patients suggests that exposure to a protein containing homology to BA21 may be important in the pathogenesis of this lymphoproliferative disorder." @default.
• W2396181853 created "2016-06-24" @default.
• W2396181853 creator A5042128541 @default.
• W2396181853 creator A5050154369 @default.
• W2396181853 creator A5052252975 @default.
• W2396181853 creator A5055624208 @default.
• W2396181853 creator A5064768170 @default.
• W2396181853 creator A5066814162 @default.
• W2396181853 creator A5087722204 @default.
• W2396181853 creator A5087869289 @default.
• W2396181853 date "1997-09-01" @default.
• W2396181853 modified "2023-09-29" @default.
• W2396181853 title "Seroreactivity to an Envelope Protein of Human T-Cell Leukemia/Lymphoma Virus in Patients With CD3− (Natural Killer) Lymphoproliferative Disease of Granular Lymphocytes" @default.
• W2396181853 cites W106878149 @default.
• W2396181853 cites W1480061065 @default.
• W2396181853 cites W1507344751 @default.
• W2396181853 cites W1517745501 @default.
• W2396181853 cites W1576197797 @default.
• W2396181853 cites W1991992194 @default.
• W2396181853 cites W2001790233 @default.
• W2396181853 cites W2023525914 @default.
• W2396181853 cites W2028828228 @default.
• W2396181853 cites W2064934792 @default.
• W2396181853 cites W2077509257 @default.
• W2396181853 cites W2101283545 @default.
• W2396181853 cites W2128949998 @default.
• W2396181853 cites W2141131605 @default.
• W2396181853 cites W2158240167 @default.
• W2396181853 cites W2412394786 @default.
• W2396181853 cites W2466712131 @default.
• W2396181853 cites W250756067 @default.
• W2396181853 cites W4230795890 @default.
• W2396181853 doi "https://doi.org/10.1182/blood.v90.5.1977" @default.
• W2396181853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9292532" @default.
• W2396181853 hasPublicationYear "1997" @default.
• W2396181853 type Work @default.
• W2396181853 sameAs 2396181853 @default.
• W2396181853 citedByCount "56" @default.
• W2396181853 countsByYear W23961818532012 @default.
• W2396181853 countsByYear W23961818532013 @default.
• W2396181853 countsByYear W23961818532014 @default.
• W2396181853 countsByYear W23961818532015 @default.
• W2396181853 countsByYear W23961818532016 @default.
• W2396181853 countsByYear W23961818532018 @default.
• W2396181853 countsByYear W23961818532019 @default.
• W2396181853 countsByYear W23961818532020 @default.
• W2396181853 countsByYear W23961818532021 @default.
• W2396181853 countsByYear W23961818532022 @default.
• W2396181853 crossrefType "journal-article" @default.
• W2396181853 hasAuthorship W2396181853A5042128541 @default.
• W2396181853 hasAuthorship W2396181853A5050154369 @default.
• W2396181853 hasAuthorship W2396181853A5052252975 @default.
• W2396181853 hasAuthorship W2396181853A5055624208 @default.
• W2396181853 hasAuthorship W2396181853A5064768170 @default.
• W2396181853 hasAuthorship W2396181853A5066814162 @default.
• W2396181853 hasAuthorship W2396181853A5087722204 @default.
• W2396181853 hasAuthorship W2396181853A5087869289 @default.
• W2396181853 hasBestOaLocation W23961818531 @default.
• W2396181853 hasConcept C147483822 @default.
• W2396181853 hasConcept C154317977 @default.
• W2396181853 hasConcept C159047783 @default.
• W2396181853 hasConcept C159654299 @default.
• W2396181853 hasConcept C195616568 @default.
• W2396181853 hasConcept C202751555 @default.
• W2396181853 hasConcept C203014093 @default.
• W2396181853 hasConcept C2522874641 @default.
• W2396181853 hasConcept C2776995267 @default.
• W2396181853 hasConcept C2778102761 @default.
• W2396181853 hasConcept C2779338263 @default.
• W2396181853 hasConcept C55493867 @default.
• W2396181853 hasConcept C86803240 @default.
• W2396181853 hasConceptScore W2396181853C147483822 @default.
• W2396181853 hasConceptScore W2396181853C154317977 @default.
• W2396181853 hasConceptScore W2396181853C159047783 @default.
• W2396181853 hasConceptScore W2396181853C159654299 @default.
• W2396181853 hasConceptScore W2396181853C195616568 @default.
• W2396181853 hasConceptScore W2396181853C202751555 @default.
• W2396181853 hasConceptScore W2396181853C203014093 @default.
• W2396181853 hasConceptScore W2396181853C2522874641 @default.
• W2396181853 hasConceptScore W2396181853C2776995267 @default.
• W2396181853 hasConceptScore W2396181853C2778102761 @default.
• W2396181853 hasConceptScore W2396181853C2779338263 @default.
• W2396181853 hasConceptScore W2396181853C55493867 @default.
• W2396181853 hasConceptScore W2396181853C86803240 @default.
• W2396181853 hasIssue "5" @default.
• W2396181853 hasLocation W23961818531 @default.
• W2396181853 hasOpenAccess W2396181853 @default.
• W2396181853 hasPrimaryLocation W23961818531 @default.
• W2396181853 hasRelatedWork W1567514421 @default.
• W2396181853 hasRelatedWork W1604248381 @default.
• W2396181853 hasRelatedWork W1872459230 @default.
• W2396181853 hasRelatedWork W2052483994 @default.
• W2396181853 hasRelatedWork W2060284918 @default.
• W2396181853 hasRelatedWork W2062407731 @default.
• W2396181853 hasRelatedWork W2136815099 @default.
• W2396181853 hasRelatedWork W2139983200 @default.
• W2396181853 hasRelatedWork W2313745184 @default.
• W2396181853 hasRelatedWork W4244618944 @default.

• next