Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396196877> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2396196877 endingPage "7" @default.
- W2396196877 startingPage "100" @default.
- W2396196877 abstract "The typical burst pattern of electrical activity recorded from beta-cells of mouse islets in the presence of 11.1 mM glucose has been compared from 225 cells in terms of two parameters: relative duration of the active phase and periodicity of the oscillations between active and silent phases. The two parameters show different distributions, Gaussian and bimodal respectively. Burst periodicity was found to increase dramatically at external potassium concentrations below 2mM, while the relative duration of the active phase was little affected at concentrations as low as 0.5 mM. Increasing external calcium concentration significantly increased the amplitude of the bursts but greatly decreased the relative duration of the active phase. Quinine, in the absence of glucose, induced depolarization and electrical activity and stimulated insulin release from perifused mouse islets; spike frequency and insulin release followed a monophasic pattern. A model has been proposed for the beta-cell explaining the experimental results in terms of a feedback mechanism between calcium permeability activated by depolarization of the cell membrane and potassium permeability activated by an increase in the concentration of intracellular ionized calcium [Ca2+]i. The results are in agreement with the hypothesis that a [Ca2+]i-dependent potassium permeability, specifically blocked by quinine, controls membrane potential and insulin release." @default.
- W2396196877 created "2016-06-24" @default.
- W2396196877 creator A5006599396 @default.
- W2396196877 creator A5016259277 @default.
- W2396196877 creator A5022128774 @default.
- W2396196877 creator A5046563494 @default.
- W2396196877 creator A5069283999 @default.
- W2396196877 date "1980-01-01" @default.
- W2396196877 modified "2023-09-26" @default.
- W2396196877 title "The nature of the oscillatory behaviour in electrical activity from pancreatic beta-cell." @default.
- W2396196877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7005051" @default.
- W2396196877 hasPublicationYear "1980" @default.
- W2396196877 type Work @default.
- W2396196877 sameAs 2396196877 @default.
- W2396196877 citedByCount "49" @default.
- W2396196877 countsByYear W23961968772013 @default.
- W2396196877 countsByYear W23961968772015 @default.
- W2396196877 countsByYear W23961968772017 @default.
- W2396196877 countsByYear W23961968772019 @default.
- W2396196877 countsByYear W23961968772022 @default.
- W2396196877 crossrefType "journal-article" @default.
- W2396196877 hasAuthorship W2396196877A5006599396 @default.
- W2396196877 hasAuthorship W2396196877A5016259277 @default.
- W2396196877 hasAuthorship W2396196877A5022128774 @default.
- W2396196877 hasAuthorship W2396196877A5046563494 @default.
- W2396196877 hasAuthorship W2396196877A5069283999 @default.
- W2396196877 hasConcept C120882062 @default.
- W2396196877 hasConcept C12554922 @default.
- W2396196877 hasConcept C126322002 @default.
- W2396196877 hasConcept C134018914 @default.
- W2396196877 hasConcept C165220095 @default.
- W2396196877 hasConcept C178790620 @default.
- W2396196877 hasConcept C181080969 @default.
- W2396196877 hasConcept C181911157 @default.
- W2396196877 hasConcept C185592680 @default.
- W2396196877 hasConcept C2779306644 @default.
- W2396196877 hasConcept C2779855799 @default.
- W2396196877 hasConcept C4141045 @default.
- W2396196877 hasConcept C41625074 @default.
- W2396196877 hasConcept C517785266 @default.
- W2396196877 hasConcept C519063684 @default.
- W2396196877 hasConcept C55493867 @default.
- W2396196877 hasConcept C71924100 @default.
- W2396196877 hasConcept C79879829 @default.
- W2396196877 hasConcept C86803240 @default.
- W2396196877 hasConceptScore W2396196877C120882062 @default.
- W2396196877 hasConceptScore W2396196877C12554922 @default.
- W2396196877 hasConceptScore W2396196877C126322002 @default.
- W2396196877 hasConceptScore W2396196877C134018914 @default.
- W2396196877 hasConceptScore W2396196877C165220095 @default.
- W2396196877 hasConceptScore W2396196877C178790620 @default.
- W2396196877 hasConceptScore W2396196877C181080969 @default.
- W2396196877 hasConceptScore W2396196877C181911157 @default.
- W2396196877 hasConceptScore W2396196877C185592680 @default.
- W2396196877 hasConceptScore W2396196877C2779306644 @default.
- W2396196877 hasConceptScore W2396196877C2779855799 @default.
- W2396196877 hasConceptScore W2396196877C4141045 @default.
- W2396196877 hasConceptScore W2396196877C41625074 @default.
- W2396196877 hasConceptScore W2396196877C517785266 @default.
- W2396196877 hasConceptScore W2396196877C519063684 @default.
- W2396196877 hasConceptScore W2396196877C55493867 @default.
- W2396196877 hasConceptScore W2396196877C71924100 @default.
- W2396196877 hasConceptScore W2396196877C79879829 @default.
- W2396196877 hasConceptScore W2396196877C86803240 @default.
- W2396196877 hasLocation W23961968771 @default.
- W2396196877 hasOpenAccess W2396196877 @default.
- W2396196877 hasPrimaryLocation W23961968771 @default.
- W2396196877 hasRelatedWork W1965188573 @default.
- W2396196877 hasRelatedWork W1974382241 @default.
- W2396196877 hasRelatedWork W1984363066 @default.
- W2396196877 hasRelatedWork W2003842308 @default.
- W2396196877 hasRelatedWork W2082047766 @default.
- W2396196877 hasRelatedWork W2086341327 @default.
- W2396196877 hasRelatedWork W2089277316 @default.
- W2396196877 hasRelatedWork W2098264346 @default.
- W2396196877 hasRelatedWork W2325773850 @default.
- W2396196877 hasRelatedWork W2441422483 @default.
- W2396196877 hasVolume "Suppl 10" @default.
- W2396196877 isParatext "false" @default.
- W2396196877 isRetracted "false" @default.
- W2396196877 magId "2396196877" @default.
- W2396196877 workType "article" @default.