FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396199123> ?p ?o ?g. }

• W2396199123 endingPage "(628)" @default.
• W2396199123 startingPage "(619)" @default.
• W2396199123 abstract "Ropivacaine, a novel long-acting local anesthetic, has been proved to own superior advantage. However, the application form used in clinic, ropivacaine hydrochloride (Naropin® Injection), which should be administed intravenously, is causing poor patient convenience. The purpose of this study was to formulate ropivacaine (RPV) in lipid nanocapsules (LNCs) and character the potential of LNCs in delivering RPV transdermally to exploit novel external preparation. The RPV-LNCs were successfully prepared by phase inversion technique and the formulation was characterized in terms of size, zeta potential, ex vivo permeation study, and pharmacodynamics. The prepared RPV-LNCs displayed a typical core-shell structure with a narrow size distribution of 62.1 ± 1.7 nm and drug loading of 1.35 ± 0.20%. The results of differential scanning calorimetry (DSC) analysis and X-ray diffraction showed that RPV was in amorphous crystalline state when encapsulated into LNCs. Furthermore, the results of ex vivo permeation study displayed that RPV-LNCs had an improved permeability (349.0 ± 11.5 μg cm−2 versus 161.0 ± 1.3 μg cm−2) compared with free RPV. The results of histopathology study showed that interaction between LNCs and skin could break the close conjugation of corneocyte layers. In the mice writhing test, RPV-LNCs exhibited obvious analgesic effect by both prolonging pain latency and reducing the writhing response with an inhibition rate of 91.3% compared to the control group. In conclusion, RPV-LNCs could be a promising delivery system to encapsulate RPV and deliver RPV for transdermal administration." @default.
• W2396199123 created "2016-06-24" @default.
• W2396199123 creator A5003115460 @default.
• W2396199123 creator A5057607115 @default.
• W2396199123 creator A5062886652 @default.
• W2396199123 creator A5080873784 @default.
• W2396199123 date "2014-07-09" @default.
• W2396199123 modified "2023-09-27" @default.
• W2396199123 title "RETRACTED ARTICLE: Preparation and characterization of novel lipid nanocapsules of ropivacaine for transdermal delivery" @default.
• W2396199123 cites W1964392630 @default.
• W2396199123 cites W1964995461 @default.
• W2396199123 cites W1968418753 @default.
• W2396199123 cites W1971313370 @default.
• W2396199123 cites W1985830405 @default.
• W2396199123 cites W1987937317 @default.
• W2396199123 cites W1988025736 @default.
• W2396199123 cites W2021465556 @default.
• W2396199123 cites W2022248147 @default.
• W2396199123 cites W2030548864 @default.
• W2396199123 cites W2048334983 @default.
• W2396199123 cites W2052768789 @default.
• W2396199123 cites W2054896476 @default.
• W2396199123 cites W2055974761 @default.
• W2396199123 cites W2056045451 @default.
• W2396199123 cites W2061346349 @default.
• W2396199123 cites W2062652730 @default.
• W2396199123 cites W2064804098 @default.
• W2396199123 cites W2064805272 @default.
• W2396199123 cites W2066807788 @default.
• W2396199123 cites W2071211938 @default.
• W2396199123 cites W2083234569 @default.
• W2396199123 cites W2083485027 @default.
• W2396199123 cites W2085911180 @default.
• W2396199123 cites W2090797092 @default.
• W2396199123 cites W2093084992 @default.
• W2396199123 cites W2130782827 @default.
• W2396199123 cites W2153813403 @default.
• W2396199123 cites W2162909204 @default.
• W2396199123 cites W2163374804 @default.
• W2396199123 cites W2166308379 @default.
• W2396199123 cites W2242170383 @default.
• W2396199123 cites W2313746009 @default.
• W2396199123 cites W3208675449 @default.
• W2396199123 cites W4240414296 @default.
• W2396199123 cites W4243768129 @default.
• W2396199123 doi "https://doi.org/10.3109/10717544.2014.930761" @default.
• W2396199123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25005584" @default.
• W2396199123 hasPublicationYear "2014" @default.
• W2396199123 type Work @default.
• W2396199123 sameAs 2396199123 @default.
• W2396199123 citedByCount "7" @default.
• W2396199123 countsByYear W23961991232016 @default.
• W2396199123 countsByYear W23961991232017 @default.
• W2396199123 countsByYear W23961991232018 @default.
• W2396199123 countsByYear W23961991232019 @default.
• W2396199123 countsByYear W23961991232020 @default.
• W2396199123 countsByYear W23961991232022 @default.
• W2396199123 crossrefType "journal-article" @default.
• W2396199123 hasAuthorship W2396199123A5003115460 @default.
• W2396199123 hasAuthorship W2396199123A5057607115 @default.
• W2396199123 hasAuthorship W2396199123A5062886652 @default.
• W2396199123 hasAuthorship W2396199123A5080873784 @default.
• W2396199123 hasConcept C121332964 @default.
• W2396199123 hasConcept C136229726 @default.
• W2396199123 hasConcept C150903083 @default.
• W2396199123 hasConcept C155672457 @default.
• W2396199123 hasConcept C171250308 @default.
• W2396199123 hasConcept C185592680 @default.
• W2396199123 hasConcept C192562407 @default.
• W2396199123 hasConcept C204399865 @default.
• W2396199123 hasConcept C205679159 @default.
• W2396199123 hasConcept C207001950 @default.
• W2396199123 hasConcept C26291073 @default.
• W2396199123 hasConcept C39519442 @default.
• W2396199123 hasConcept C41625074 @default.
• W2396199123 hasConcept C50670333 @default.
• W2396199123 hasConcept C55493867 @default.
• W2396199123 hasConcept C71924100 @default.
• W2396199123 hasConcept C86803240 @default.
• W2396199123 hasConcept C97355855 @default.
• W2396199123 hasConcept C98274493 @default.
• W2396199123 hasConceptScore W2396199123C121332964 @default.
• W2396199123 hasConceptScore W2396199123C136229726 @default.
• W2396199123 hasConceptScore W2396199123C150903083 @default.
• W2396199123 hasConceptScore W2396199123C155672457 @default.
• W2396199123 hasConceptScore W2396199123C171250308 @default.
• W2396199123 hasConceptScore W2396199123C185592680 @default.
• W2396199123 hasConceptScore W2396199123C192562407 @default.
• W2396199123 hasConceptScore W2396199123C204399865 @default.
• W2396199123 hasConceptScore W2396199123C205679159 @default.
• W2396199123 hasConceptScore W2396199123C207001950 @default.
• W2396199123 hasConceptScore W2396199123C26291073 @default.
• W2396199123 hasConceptScore W2396199123C39519442 @default.
• W2396199123 hasConceptScore W2396199123C41625074 @default.
• W2396199123 hasConceptScore W2396199123C50670333 @default.
• W2396199123 hasConceptScore W2396199123C55493867 @default.
• W2396199123 hasConceptScore W2396199123C71924100 @default.
• W2396199123 hasConceptScore W2396199123C86803240 @default.

• next