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- W2396204023 endingPage "8223" @default.
- W2396204023 startingPage "8204" @default.
- W2396204023 abstract "Nicotinic acetylcholine receptors (nAChRs) have been investigated for developing drugs that can potentially treat various central nervous system disorders. Considerable evidence supports the hypothesis that modulation of the cholinergic system through activation and/or desensitization/inactivation of nAChR holds promise for the development of new antidepressants. The introductory portion of this Miniperspective discusses the basic pharmacology that underpins the involvement of α4β2-nAChRs in depression, along with the structural features that are essential to ligand recognition by the α4β2-nAChRs. The remainder of this Miniperspective analyzes reported nicotinic ligands in terms of drug design considerations and their potency and selectivity, with a particular focus on compounds exhibiting antidepressant-like effects in preclinical or clinical studies. This Miniperspective aims to provide an in-depth analysis of the potential for using nicotinic ligands in the treatment of depression, which may hold some promise in addressing an unmet clinical need by providing relief from depressive symptoms in refractory patients." @default.
- W2396204023 created "2016-06-24" @default.
- W2396204023 creator A5005118391 @default.
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- W2396204023 creator A5051984376 @default.
- W2396204023 creator A5061573225 @default.
- W2396204023 creator A5083370387 @default.
- W2396204023 date "2014-07-02" @default.
- W2396204023 modified "2023-10-17" @default.
- W2396204023 title "Recent Developments in Novel Antidepressants Targeting α4β2-Nicotinic Acetylcholine Receptors" @default.
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