Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396246458> ?p ?o ?g. }
- W2396246458 endingPage "251" @default.
- W2396246458 startingPage "245" @default.
- W2396246458 abstract "Paracoccidioidomycosis (PCM) is a systemic chronic mycosis, endemic in Latin America, especially Brazil, and is the eighth leading cause of death among chronic and recurrent infectious diseases. PCM infection is characterized by the presence of Th1 immune response; the acute form, by a mixed Th2/Th9, while the chronic form is characterized by Th17/Th22 profiles. The occurrence and severity of human PCM may also be associated with genetic factors such as single nucleotide polymorphisms (SNP) on cytokines encoding genes. We investigated the association between these polymorphisms and the different clinical forms of PCM. We included 156 patients with PCM (40 with the acute form, 99 with the chronic multifocal and 17 with the chronic unifocal form) and assayed their DNA samples for IFNG + 874 T/A SNP by PCR-ARMS (Amplification Refractory Mutational System), IL12B + 1188 A/C SNP on 3′ UTR and IL12RB1 641 A/G SNP on exon 7 by PCR-RFLP (Restriction Fragment Length Polymorphism). We found similar genotypic and allelic frequencies of the investigated SNPs among the clinical forms of PCM. Considering male patients, the IL12RB1 641 AA genotype was more frequent in the chronic multifocal form while heterozygosis was in the chronic unifocal form of PCM (p = 0.048). Although our data suggest that the AA genotype (IL12RB1) may be associated with the more disseminated chronic disease, more patients of the chronic unifocal PCM group need to be analyzed as well as the secretion patterns of IFN-γ combined with the IL-12Rβ1 expression for a better comprehension of this association." @default.
- W2396246458 created "2016-06-24" @default.
- W2396246458 creator A5004292375 @default.
- W2396246458 creator A5008015841 @default.
- W2396246458 creator A5016431865 @default.
- W2396246458 creator A5042590100 @default.
- W2396246458 creator A5049996158 @default.
- W2396246458 creator A5052820730 @default.
- W2396246458 creator A5055444907 @default.
- W2396246458 creator A5062740243 @default.
- W2396246458 creator A5062976790 @default.
- W2396246458 creator A5089653562 @default.
- W2396246458 date "2016-09-01" @default.
- W2396246458 modified "2023-10-18" @default.
- W2396246458 title "Polymorphisms on IFNG , IL12B and IL12RB1 genes and paracoccidioidomycosis in the Brazilian population" @default.
- W2396246458 cites W1481608537 @default.
- W2396246458 cites W1489303745 @default.
- W2396246458 cites W1490925550 @default.
- W2396246458 cites W1812585379 @default.
- W2396246458 cites W186423065 @default.
- W2396246458 cites W1955881849 @default.
- W2396246458 cites W1968230870 @default.
- W2396246458 cites W1968813509 @default.
- W2396246458 cites W1973942391 @default.
- W2396246458 cites W1973985508 @default.
- W2396246458 cites W1975217762 @default.
- W2396246458 cites W1980442297 @default.
- W2396246458 cites W1982452097 @default.
- W2396246458 cites W1982903145 @default.
- W2396246458 cites W2011703513 @default.
- W2396246458 cites W2013948033 @default.
- W2396246458 cites W2015267770 @default.
- W2396246458 cites W2019277327 @default.
- W2396246458 cites W2019287801 @default.
- W2396246458 cites W2020132613 @default.
- W2396246458 cites W2020648412 @default.
- W2396246458 cites W2027124691 @default.
- W2396246458 cites W2029322084 @default.
- W2396246458 cites W2044325609 @default.
- W2396246458 cites W2048883307 @default.
- W2396246458 cites W2053294798 @default.
- W2396246458 cites W2054589217 @default.
- W2396246458 cites W2055846363 @default.
- W2396246458 cites W2056171217 @default.
- W2396246458 cites W2058928443 @default.
- W2396246458 cites W2059377898 @default.
- W2396246458 cites W2061286588 @default.
- W2396246458 cites W2061573881 @default.
- W2396246458 cites W2062891909 @default.
- W2396246458 cites W2067722911 @default.
- W2396246458 cites W2067786393 @default.
- W2396246458 cites W2068610233 @default.
- W2396246458 cites W2078956320 @default.
- W2396246458 cites W2079064760 @default.
- W2396246458 cites W2079277215 @default.
- W2396246458 cites W2081028743 @default.
- W2396246458 cites W2081516262 @default.
- W2396246458 cites W2087905758 @default.
- W2396246458 cites W2088975602 @default.
- W2396246458 cites W2091737500 @default.
- W2396246458 cites W2095048402 @default.
- W2396246458 cites W2099676440 @default.
- W2396246458 cites W2101036822 @default.
- W2396246458 cites W2104866075 @default.
- W2396246458 cites W2117038718 @default.
- W2396246458 cites W2118512649 @default.
- W2396246458 cites W2119574025 @default.
- W2396246458 cites W2123720885 @default.
- W2396246458 cites W2135254713 @default.
- W2396246458 cites W2140600672 @default.
- W2396246458 cites W2143804392 @default.
- W2396246458 cites W2144452473 @default.
- W2396246458 cites W2146347216 @default.
- W2396246458 cites W2147459815 @default.
- W2396246458 cites W2159253964 @default.
- W2396246458 cites W2159876820 @default.
- W2396246458 cites W2163301438 @default.
- W2396246458 cites W2165009109 @default.
- W2396246458 cites W2165511567 @default.
- W2396246458 cites W2165606268 @default.
- W2396246458 cites W2278894526 @default.
- W2396246458 cites W2400729270 @default.
- W2396246458 cites W2497930728 @default.
- W2396246458 cites W2996631976 @default.
- W2396246458 cites W4239937288 @default.
- W2396246458 cites W63909035 @default.
- W2396246458 doi "https://doi.org/10.1016/j.meegid.2016.05.025" @default.
- W2396246458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27223631" @default.
- W2396246458 hasPublicationYear "2016" @default.
- W2396246458 type Work @default.
- W2396246458 sameAs 2396246458 @default.
- W2396246458 citedByCount "14" @default.
- W2396246458 countsByYear W23962464582017 @default.
- W2396246458 countsByYear W23962464582018 @default.
- W2396246458 countsByYear W23962464582019 @default.
- W2396246458 countsByYear W23962464582020 @default.
- W2396246458 countsByYear W23962464582021 @default.
- W2396246458 countsByYear W23962464582023 @default.