Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396252337> ?p ?o ?g. }
- W2396252337 abstract "Human milk (HM) contains regulatory biomolecules including miRNAs, the origin and functional significance of which are still undetermined. We used TaqMan OpenArrays to profile 681 mature miRNAs in HM cells and fat, and compared them with maternal peripheral blood mononuclear cells (PBMCs) and plasma, and bovine and soy infant formulae. HM cells and PBMCs (292 and 345 miRNAs, respectively) had higher miRNA content than HM fat and plasma (242 and 219 miRNAs, respectively) (p < 0.05). A strong association in miRNA profiles was found between HM cells and fat, whilst PBMCs and plasma were distinctly different to HM, displaying marked inter-individual variation. Considering the dominance of epithelial cells in mature milk of healthy women, these results suggest that HM miRNAs primarily originate from the mammary epithelium, whilst the maternal circulation may have a smaller contribution. Our findings demonstrate that unlike infant formulae, which contained very few human miRNA, HM is a rich source of lactation-specific miRNA, which could be used as biomarkers of the performance and health status of the lactating mammary gland. Given the recently identified stability, uptake and functionality of food- and milk-derived miRNA in vivo, HM miRNA are likely to contribute to infant protection and development." @default.
- W2396252337 created "2016-06-24" @default.
- W2396252337 creator A5003942091 @default.
- W2396252337 creator A5017501856 @default.
- W2396252337 creator A5024634924 @default.
- W2396252337 creator A5035588768 @default.
- W2396252337 creator A5053679702 @default.
- W2396252337 date "2016-02-01" @default.
- W2396252337 modified "2023-10-14" @default.
- W2396252337 title "Human milk miRNAs primarily originate from the mammary gland resulting in unique miRNA profiles of fractionated milk" @default.
- W2396252337 cites W1176278669 @default.
- W2396252337 cites W144423133 @default.
- W2396252337 cites W1845309771 @default.
- W2396252337 cites W1859042441 @default.
- W2396252337 cites W1922230241 @default.
- W2396252337 cites W1927705775 @default.
- W2396252337 cites W1944302816 @default.
- W2396252337 cites W1971874638 @default.
- W2396252337 cites W1979440527 @default.
- W2396252337 cites W1983376923 @default.
- W2396252337 cites W1985489555 @default.
- W2396252337 cites W1990406446 @default.
- W2396252337 cites W1993713997 @default.
- W2396252337 cites W1994758859 @default.
- W2396252337 cites W2000286733 @default.
- W2396252337 cites W2002995168 @default.
- W2396252337 cites W2016960054 @default.
- W2396252337 cites W2022231246 @default.
- W2396252337 cites W2045608491 @default.
- W2396252337 cites W2046864190 @default.
- W2396252337 cites W2047967134 @default.
- W2396252337 cites W2055313665 @default.
- W2396252337 cites W2057455941 @default.
- W2396252337 cites W2059357290 @default.
- W2396252337 cites W2062463567 @default.
- W2396252337 cites W2073315752 @default.
- W2396252337 cites W2076556926 @default.
- W2396252337 cites W2079659181 @default.
- W2396252337 cites W2081113032 @default.
- W2396252337 cites W2085832350 @default.
- W2396252337 cites W2092156814 @default.
- W2396252337 cites W2097233439 @default.
- W2396252337 cites W2099196117 @default.
- W2396252337 cites W2102122219 @default.
- W2396252337 cites W2102750482 @default.
- W2396252337 cites W2104116256 @default.
- W2396252337 cites W2107718722 @default.
- W2396252337 cites W2109480277 @default.
- W2396252337 cites W2111663113 @default.
- W2396252337 cites W2120698857 @default.
- W2396252337 cites W2129802808 @default.
- W2396252337 cites W2130715746 @default.
- W2396252337 cites W2131848047 @default.
- W2396252337 cites W2141491081 @default.
- W2396252337 cites W2142221925 @default.
- W2396252337 cites W2144989127 @default.
- W2396252337 cites W2145025818 @default.
- W2396252337 cites W2151187882 @default.
- W2396252337 cites W2161068194 @default.
- W2396252337 cites W2162170048 @default.
- W2396252337 cites W2163113687 @default.
- W2396252337 cites W2163627040 @default.
- W2396252337 cites W2163694561 @default.
- W2396252337 cites W2165374397 @default.
- W2396252337 cites W2165817513 @default.
- W2396252337 cites W2166763675 @default.
- W2396252337 cites W2189880526 @default.
- W2396252337 cites W2258999208 @default.
- W2396252337 cites W2292343120 @default.
- W2396252337 cites W2470224098 @default.
- W2396252337 cites W2597632520 @default.
- W2396252337 cites W4212888212 @default.
- W2396252337 cites W4302321916 @default.
- W2396252337 cites W2341894198 @default.
- W2396252337 doi "https://doi.org/10.1038/srep20680" @default.
- W2396252337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4745068" @default.
- W2396252337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26854194" @default.
- W2396252337 hasPublicationYear "2016" @default.
- W2396252337 type Work @default.
- W2396252337 sameAs 2396252337 @default.
- W2396252337 citedByCount "132" @default.
- W2396252337 countsByYear W23962523372015 @default.
- W2396252337 countsByYear W23962523372016 @default.
- W2396252337 countsByYear W23962523372017 @default.
- W2396252337 countsByYear W23962523372018 @default.
- W2396252337 countsByYear W23962523372019 @default.
- W2396252337 countsByYear W23962523372020 @default.
- W2396252337 countsByYear W23962523372021 @default.
- W2396252337 countsByYear W23962523372022 @default.
- W2396252337 countsByYear W23962523372023 @default.
- W2396252337 crossrefType "journal-article" @default.
- W2396252337 hasAuthorship W2396252337A5003942091 @default.
- W2396252337 hasAuthorship W2396252337A5017501856 @default.
- W2396252337 hasAuthorship W2396252337A5024634924 @default.
- W2396252337 hasAuthorship W2396252337A5035588768 @default.
- W2396252337 hasAuthorship W2396252337A5053679702 @default.
- W2396252337 hasBestOaLocation W23962523371 @default.
- W2396252337 hasConcept C104317684 @default.
- W2396252337 hasConcept C121608353 @default.
- W2396252337 hasConcept C137061746 @default.