Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396268962> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2396268962 endingPage "9" @default.
- W2396268962 startingPage "422" @default.
- W2396268962 abstract "Imipenem, cefaperazon-sulbactam and cefepime are the antibiotics of choice for the treatment of soft tissue infections due to Acinetobacter baumannii. In this study, it was aimed to determine the invivo and invitro efficacy of, these antibiotics against drug susceptible and multidrug resistant A.baumannii in an experimental abscess model. Abscess models were established in Wistar-Albino type female rats. Susceptibility tests were performed by E-test. Rats were divided randomly into four groups with eight rats in one group. Standard absorbent paper discs containing 6 log10 CFU microorganisms were used to form an abscess model. The first group was regarded as the control group and the other three groups were the study group each treated with one of the test antibiotics. Cardiac blood samples for serum antibiotic efficacy test, were obtained on the fourth day of treatment and 30 minutes after the last dose. The number of live bacteria at the area of infection was determined by colony count method. All of the three antibiotics reached sufficient concentration in sera of rats and there were no statistically important difference between the efficacies of these antibiotics (p= 0.778). In all of the antibiotic-treated groups, the weight of the abscess material were less, macroscopic views were smaller and the colony counts per gram of abscess tissue were less than the control group (p< 0.001). All antibiotics were effective against susceptible and resistant strains in vitro. No resistance was detected against imipenem, cefaperazon-sulbactam and cefepime in the course of therapy. Cefaperazone-sulbactam and cefepime were as effective as imipenem against susceptible and multi-drug resistant A.baumannii both in vivo and in vitro. Since irrational use of extended spectrum cephalosporins are frequently associated with the emergence of carbapenem resistant strains, the use of relatively narrow spectrum antibiotics should better be considered in the empirical treatment of A.baumannii infections." @default.
- W2396268962 created "2016-06-24" @default.
- W2396268962 creator A5007967179 @default.
- W2396268962 creator A5010420234 @default.
- W2396268962 date "2011-07-01" @default.
- W2396268962 modified "2023-09-23" @default.
- W2396268962 title "[Assessment of efficacies of imipenem, cefoperazone-sulbactam and cefepime in rats with experimental thigh abscess model with multidrug resistant and susceptible Acinetobacter baumannii strains]." @default.
- W2396268962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21935775" @default.
- W2396268962 hasPublicationYear "2011" @default.
- W2396268962 type Work @default.
- W2396268962 sameAs 2396268962 @default.
- W2396268962 citedByCount "1" @default.
- W2396268962 countsByYear W23962689622016 @default.
- W2396268962 crossrefType "journal-article" @default.
- W2396268962 hasAuthorship W2396268962A5007967179 @default.
- W2396268962 hasAuthorship W2396268962A5010420234 @default.
- W2396268962 hasConcept C2776315533 @default.
- W2396268962 hasConcept C2776432923 @default.
- W2396268962 hasConcept C2777050379 @default.
- W2396268962 hasConcept C2777637488 @default.
- W2396268962 hasConcept C2778478555 @default.
- W2396268962 hasConcept C2778523567 @default.
- W2396268962 hasConcept C2779631663 @default.
- W2396268962 hasConcept C501593827 @default.
- W2396268962 hasConcept C523546767 @default.
- W2396268962 hasConcept C54355233 @default.
- W2396268962 hasConcept C71924100 @default.
- W2396268962 hasConcept C86803240 @default.
- W2396268962 hasConcept C89423630 @default.
- W2396268962 hasConcept C94665300 @default.
- W2396268962 hasConceptScore W2396268962C2776315533 @default.
- W2396268962 hasConceptScore W2396268962C2776432923 @default.
- W2396268962 hasConceptScore W2396268962C2777050379 @default.
- W2396268962 hasConceptScore W2396268962C2777637488 @default.
- W2396268962 hasConceptScore W2396268962C2778478555 @default.
- W2396268962 hasConceptScore W2396268962C2778523567 @default.
- W2396268962 hasConceptScore W2396268962C2779631663 @default.
- W2396268962 hasConceptScore W2396268962C501593827 @default.
- W2396268962 hasConceptScore W2396268962C523546767 @default.
- W2396268962 hasConceptScore W2396268962C54355233 @default.
- W2396268962 hasConceptScore W2396268962C71924100 @default.
- W2396268962 hasConceptScore W2396268962C86803240 @default.
- W2396268962 hasConceptScore W2396268962C89423630 @default.
- W2396268962 hasConceptScore W2396268962C94665300 @default.
- W2396268962 hasIssue "3" @default.
- W2396268962 hasLocation W23962689621 @default.
- W2396268962 hasOpenAccess W2396268962 @default.
- W2396268962 hasPrimaryLocation W23962689621 @default.
- W2396268962 hasRelatedWork W1875938754 @default.
- W2396268962 hasRelatedWork W1992691594 @default.
- W2396268962 hasRelatedWork W2079225684 @default.
- W2396268962 hasRelatedWork W2337493486 @default.
- W2396268962 hasRelatedWork W2348092587 @default.
- W2396268962 hasRelatedWork W2358598773 @default.
- W2396268962 hasRelatedWork W2359628414 @default.
- W2396268962 hasRelatedWork W2369192896 @default.
- W2396268962 hasRelatedWork W2389314917 @default.
- W2396268962 hasRelatedWork W2396268962 @default.
- W2396268962 hasVolume "45" @default.
- W2396268962 isParatext "false" @default.
- W2396268962 isRetracted "false" @default.
- W2396268962 magId "2396268962" @default.
- W2396268962 workType "article" @default.