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• W2396311143 abstract "No AccessJournal of Urology1 Feb 1989Immunocytochemical Demonstration of S Phase Cells by Antlbromobeoxyuribine Monoclonal Antibody in Human Prostate Adenocarcinoma Ryosuke Nemoto, Katsunori Uchida, Toru Shimazui, Kazunori Hattori, Kenkichi Koiso, and Masaoki Harada Ryosuke NemotoRyosuke Nemoto More articles by this author , Katsunori UchidaKatsunori Uchida More articles by this author , Toru ShimazuiToru Shimazui More articles by this author , Kazunori HattoriKazunori Hattori More articles by this author , Kenkichi KoisoKenkichi Koiso More articles by this author , and Masaoki HaradaMasaoki Harada More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)40760-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Using a monoclonal antibody to bromodeoxyuridine and immunohistochemistry, we measured the incorporation of this thymidine analogue into the deoxyribonucleic acid of human prostate adenocarcinoma cells exposed in situ. Fifteen patients with prostate cancer were given an intravenous infusion of 500mg. bromodeoxyuridine at needle biopsy to label tumor cells in the deoxyribonucleic acid synthesis phase (S phase). The tumor specimens were fixed with 70 per cent ethanol, embedded in paraffin, sectioned and stained by an indirect immunoperoxidase method using anti-bromodeoxyuridine monoclonal antibody as the first antibody. The results showed that this method demonstrated bromodeoxyuridine-labeled nuclei satisfactorily in tissue section. The bromodeoxyuridine labeling index, S phase fraction, was determined by counting the number of bromodeoxyuridine-labeled cells in the tissue sections. Grade 3 tumors averaged 4.37 ± 0.48 per cent labeling versus 2.41 ± 0.49 per cent in grade 2 tumors, and grade 1 tumor in the series had an S phase fraction of 1.36 ± 0.39 per cent. The average S phase fractions for single gland, cribriform, fused and medullary were 1.16, 2.30, 3.74 and 4.95 per cent, respectively. The results obtained with S phase fraction measured with bromodeoxyuridine labeling proved to be comparable to the results of histological grade and growth pattern. Thus, the higher S phase fraction may indicate biological malignancy. Moreover, the degree of heterogeneity concerning S phase fraction distribution within prostate cancer tissue could be compared to the morphological appearance. Our preliminary results suggest that the measurement of bromodeoxyuridine labeling index in prostate cancer may prove to be a new objective and quantitative assay of biological potential of individual tumor. © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByNemoto R, Kawamura H, Miyakawa I, Uchida K, Hattori K, Koiso K and Harada M (2018) Immunohistochemical Detection of Proliferating Cell Nuclear Antigen (Pcna)/Cyclin in Human Prostate AdenocarcinomaJournal of Urology, VOL. 149, NO. 1, (165-169), Online publication date: 1-Jan-1993.Scrivner D, Meyer J, Rujanavech N, Fathman A and Scully T (2018) Cell Kinetics by Bromodeoxyuridine Labeling and Deoxyribonucleic Acid Ploidy in Prostatic Carcinoma Needle BiopsiesJournal of Urology, VOL. 146, NO. 4, (1034-1039), Online publication date: 1-Oct-1991.Oomens E, Van Steenbrugge G, Van Der Kwast T and Schröder F (2018) Application of the Monoclonal Antibody Ki-67 on Prostate Biopsies to Assess the Proliferative Cell Fraction of Human Prostatic CarcinomaJournal of Urology, VOL. 145, NO. 1, (81-85), Online publication date: 1-Jan-1991.Gallee M, Jong E, Kate F, Schroeder F and Van Der Kwast T (2018) Monoclonal Antibody KI-67 Defined Growth Fraction in Benign Prostatic Hyperplasia and Prostatic CancerJournal of Urology, VOL. 142, NO. 5, (1342-1346), Online publication date: 1-Nov-1989. Volume 141Issue 2February 1989Page: 337-340 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Ryosuke Nemoto More articles by this author Katsunori Uchida More articles by this author Toru Shimazui More articles by this author Kazunori Hattori More articles by this author Kenkichi Koiso More articles by this author Masaoki Harada More articles by this author Expand All Advertisement Loading ..." @default.
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• W2396311143 title "Immunocytochemical Demonstration of S Phase Cells by Antlbromobeoxyuribine Monoclonal Antibody in Human Prostate Adenocarcinoma" @default.
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