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- W2396343022 abstract "Given alginate's contribution to Pseudomonas aeruginosa virulence, it has long been considered a promising target for interventional therapies, which have been performed by using the enzyme alginate lyase. In this work, instead of treating pre-established mucoid biofilms, alginate lyase is immobilized onto a surface as a preventive measure against P. aeruginosa adhesion. A polydopamine dip-coating strategy is employed for functionalization of polycarbonate surfaces. Enzyme immobilization is confirmed by surface characterization. Surfaces functionalized with alginate lyase exhibit anti-adhesive properties, inhibiting the attachment of the mucoid strain. Moreover, surfaces modified with this enzyme also inhibit the adhesion of the tested non-mucoid strain. Unexpectedly, treatment with heat-inactivated enzyme also inhibits the attachment of mucoid and non-mucoid P. aeruginosa strains. These findings suggest that the antibacterial performance of alginate lyase functional coatings is catalysis-independent, highlighting the importance of further studies to better understand its mechanism of action against P. aeruginosa strains." @default.
- W2396343022 created "2016-06-24" @default.
- W2396343022 creator A5013738849 @default.
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- W2396343022 date "2016-05-19" @default.
- W2396343022 modified "2023-10-06" @default.
- W2396343022 title "Polydopamine-Mediated Immobilization of Alginate Lyase to Prevent<i>P. aeruginosa</i>Adhesion" @default.
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- W2396343022 doi "https://doi.org/10.1002/mabi.201600077" @default.
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