Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396356502> ?p ?o ?g. }
- W2396356502 endingPage "351" @default.
- W2396356502 startingPage "345" @default.
- W2396356502 abstract "Starvation for 6h and 24h caused an 80% and 95% decrease in the rate of mammary-gland lipogenesis respectively in conscious lactating rats. 2. Plasma insulin concentrations decreased and circulating ketone-body concentrations increased with the length of starvation. 3. The inhibition of lipogenesis after 24h starvation was accompanied by increased concentrations of glucose, glucose 6-phosphate and citrate in the mammary gland. Qualitatively similar changes were observed after 6h starvation. 4. Infusion of insulin at physiological concentrations caused a 100% increase in the rate of lipogenesis in fed animals and partially reversed the inhibition of lipogenesis caused by starvation. 5. Infusion of insulin tended to reverse the changes seen in intracellular metabolite concentrations. 4. Infusion of glucagon into fed rats caused no change in the rates of lipogenesis in mammary gland, liver or white adipose tissue. 7. It is concluded that (a) insulin acts physiologically to regulate lipogenesis in the mammary gland, (b) hexokinase and phosphofructokinase are important regulatory enzymes in the short-term control of lipogenesis in the mammary gland, which are under the influence of insulin, and (c) the unresponsiveness of mammary-gland lipogenesis in vivo to infusions of glucagon is consistent with an adaptive mechanism which diverts substrate towards the lactating mammary gland and away from other tissues." @default.
- W2396356502 created "2016-06-24" @default.
- W2396356502 creator A5002521218 @default.
- W2396356502 creator A5044900754 @default.
- W2396356502 creator A5071380624 @default.
- W2396356502 date "1984-10-15" @default.
- W2396356502 modified "2023-09-26" @default.
- W2396356502 title "Regulation of lactating-rat mammary-gland lipogenesis by insulin and glucagon <i>in vivo</i>. The role and site of action of insulin in the transition to the starved state" @default.
- W2396356502 cites W1245051082 @default.
- W2396356502 cites W136196346 @default.
- W2396356502 cites W1531062343 @default.
- W2396356502 cites W1844380944 @default.
- W2396356502 cites W1874547427 @default.
- W2396356502 cites W1971995959 @default.
- W2396356502 cites W1972892862 @default.
- W2396356502 cites W1980122380 @default.
- W2396356502 cites W1994989824 @default.
- W2396356502 cites W2008861614 @default.
- W2396356502 cites W2009861805 @default.
- W2396356502 cites W2011986264 @default.
- W2396356502 cites W202864358 @default.
- W2396356502 cites W2049349819 @default.
- W2396356502 cites W2056948458 @default.
- W2396356502 cites W2067178645 @default.
- W2396356502 cites W2073725361 @default.
- W2396356502 cites W2092288015 @default.
- W2396356502 cites W2147207948 @default.
- W2396356502 cites W2195476236 @default.
- W2396356502 cites W2216853829 @default.
- W2396356502 cites W2237616359 @default.
- W2396356502 cites W2283431767 @default.
- W2396356502 cites W2339557541 @default.
- W2396356502 cites W2340663660 @default.
- W2396356502 cites W2406288067 @default.
- W2396356502 cites W2475066559 @default.
- W2396356502 cites W2988869127 @default.
- W2396356502 cites W40104989 @default.
- W2396356502 cites W59694120 @default.
- W2396356502 cites W62898540 @default.
- W2396356502 cites W946754059 @default.
- W2396356502 doi "https://doi.org/10.1042/bj2230345" @default.
- W2396356502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1144306" @default.
- W2396356502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6388568" @default.
- W2396356502 hasPublicationYear "1984" @default.
- W2396356502 type Work @default.
- W2396356502 sameAs 2396356502 @default.
- W2396356502 citedByCount "46" @default.
- W2396356502 countsByYear W23963565022012 @default.
- W2396356502 countsByYear W23963565022013 @default.
- W2396356502 countsByYear W23963565022022 @default.
- W2396356502 crossrefType "journal-article" @default.
- W2396356502 hasAuthorship W2396356502A5002521218 @default.
- W2396356502 hasAuthorship W2396356502A5044900754 @default.
- W2396356502 hasAuthorship W2396356502A5071380624 @default.
- W2396356502 hasBestOaLocation W23963565022 @default.
- W2396356502 hasConcept C121608353 @default.
- W2396356502 hasConcept C126322002 @default.
- W2396356502 hasConcept C134018914 @default.
- W2396356502 hasConcept C141359234 @default.
- W2396356502 hasConcept C185592680 @default.
- W2396356502 hasConcept C2778001805 @default.
- W2396356502 hasConcept C2778563252 @default.
- W2396356502 hasConcept C2779306644 @default.
- W2396356502 hasConcept C31532488 @default.
- W2396356502 hasConcept C4733338 @default.
- W2396356502 hasConcept C530470458 @default.
- W2396356502 hasConcept C62231903 @default.
- W2396356502 hasConcept C71924100 @default.
- W2396356502 hasConcept C86803240 @default.
- W2396356502 hasConceptScore W2396356502C121608353 @default.
- W2396356502 hasConceptScore W2396356502C126322002 @default.
- W2396356502 hasConceptScore W2396356502C134018914 @default.
- W2396356502 hasConceptScore W2396356502C141359234 @default.
- W2396356502 hasConceptScore W2396356502C185592680 @default.
- W2396356502 hasConceptScore W2396356502C2778001805 @default.
- W2396356502 hasConceptScore W2396356502C2778563252 @default.
- W2396356502 hasConceptScore W2396356502C2779306644 @default.
- W2396356502 hasConceptScore W2396356502C31532488 @default.
- W2396356502 hasConceptScore W2396356502C4733338 @default.
- W2396356502 hasConceptScore W2396356502C530470458 @default.
- W2396356502 hasConceptScore W2396356502C62231903 @default.
- W2396356502 hasConceptScore W2396356502C71924100 @default.
- W2396356502 hasConceptScore W2396356502C86803240 @default.
- W2396356502 hasIssue "2" @default.
- W2396356502 hasLocation W23963565021 @default.
- W2396356502 hasLocation W23963565022 @default.
- W2396356502 hasLocation W23963565023 @default.
- W2396356502 hasLocation W23963565024 @default.
- W2396356502 hasOpenAccess W2396356502 @default.
- W2396356502 hasPrimaryLocation W23963565021 @default.
- W2396356502 hasRelatedWork W1974106130 @default.
- W2396356502 hasRelatedWork W1986101904 @default.
- W2396356502 hasRelatedWork W2018315084 @default.
- W2396356502 hasRelatedWork W2026928593 @default.
- W2396356502 hasRelatedWork W2084131229 @default.
- W2396356502 hasRelatedWork W2089642577 @default.
- W2396356502 hasRelatedWork W2097857221 @default.
- W2396356502 hasRelatedWork W2153868682 @default.