Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396389010> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2396389010 endingPage "11" @default.
- W2396389010 startingPage "3" @default.
- W2396389010 abstract "An experimental model for testing vasodilating drugs on vasospasm caused by standardized traumatisation of a pedicle has not been described yet. The aim of this study was to develop such model and to compare the effects of different types of surgical manipulations that can provoke vasospasm during flap dissection.The pedicled groin flap was dissected in 185 male Wistar rats under standardised conditions. The blood perfusion curves of the flap were obtained using the Laser Doppler flow-meter. The vasospasm was provoked by the following manoeuvres: pulling on the pedicle; compression of the pedicle by vascular clamps; dissection of the vessels and by presence of blood around the pedicle. The perfusion recording curves were processed and two important time periods describing the progress of spasm were extracted. Combined non-parametrical ANOVA and WILCOXON tests were used to compare the time parameters between the groups. On the basis of statistical evaluation, we divided the factors responsible for vasospasm into categories labelled as strong and weak. The strong stimuli included dissection of the vessels; pulling on the pedicle using 15g, 20g and 25g weights and presence of blood around the pedicle. The weak stimuli included compression of the pedicle using vascular clamps and pulling on the pedicle using 10g weight. Pulling on the pedicle using 15g weight was chosen as the most appropriate stimulus for the experimental model.A new experimental model for studying vasospasm caused by tension on the pedicle was developed. This model is well defined, easily repeatable and reproducible, produces vasospasm of appropriate duration and permits standardized topical application of vasodilating drugs.The finding that certain kind of surgical traumatisation causes vasospasm that is longer than the others may help microsurgeons to review their methods of surgical manipulation." @default.
- W2396389010 created "2016-06-24" @default.
- W2396389010 creator A5008061712 @default.
- W2396389010 creator A5024196894 @default.
- W2396389010 creator A5024371392 @default.
- W2396389010 creator A5073431969 @default.
- W2396389010 creator A5074329869 @default.
- W2396389010 creator A5086675491 @default.
- W2396389010 date "2014-01-01" @default.
- W2396389010 modified "2023-09-29" @default.
- W2396389010 title "Vasospasm of the flap pedicle - the new experimental model on rat." @default.
- W2396389010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25484270" @default.
- W2396389010 hasPublicationYear "2014" @default.
- W2396389010 type Work @default.
- W2396389010 sameAs 2396389010 @default.
- W2396389010 citedByCount "1" @default.
- W2396389010 countsByYear W23963890102023 @default.
- W2396389010 crossrefType "journal-article" @default.
- W2396389010 hasAuthorship W2396389010A5008061712 @default.
- W2396389010 hasAuthorship W2396389010A5024196894 @default.
- W2396389010 hasAuthorship W2396389010A5024371392 @default.
- W2396389010 hasAuthorship W2396389010A5073431969 @default.
- W2396389010 hasAuthorship W2396389010A5074329869 @default.
- W2396389010 hasAuthorship W2396389010A5086675491 @default.
- W2396389010 hasConcept C141071460 @default.
- W2396389010 hasConcept C146957229 @default.
- W2396389010 hasConcept C158846371 @default.
- W2396389010 hasConcept C164705383 @default.
- W2396389010 hasConcept C2775862295 @default.
- W2396389010 hasConcept C2777736543 @default.
- W2396389010 hasConcept C2778506911 @default.
- W2396389010 hasConcept C42219234 @default.
- W2396389010 hasConcept C71924100 @default.
- W2396389010 hasConceptScore W2396389010C141071460 @default.
- W2396389010 hasConceptScore W2396389010C146957229 @default.
- W2396389010 hasConceptScore W2396389010C158846371 @default.
- W2396389010 hasConceptScore W2396389010C164705383 @default.
- W2396389010 hasConceptScore W2396389010C2775862295 @default.
- W2396389010 hasConceptScore W2396389010C2777736543 @default.
- W2396389010 hasConceptScore W2396389010C2778506911 @default.
- W2396389010 hasConceptScore W2396389010C42219234 @default.
- W2396389010 hasConceptScore W2396389010C71924100 @default.
- W2396389010 hasIssue "1-2" @default.
- W2396389010 hasLocation W23963890101 @default.
- W2396389010 hasOpenAccess W2396389010 @default.
- W2396389010 hasPrimaryLocation W23963890101 @default.
- W2396389010 hasRelatedWork W2003938723 @default.
- W2396389010 hasRelatedWork W2019517015 @default.
- W2396389010 hasRelatedWork W2118496982 @default.
- W2396389010 hasRelatedWork W2140607528 @default.
- W2396389010 hasRelatedWork W2364998975 @default.
- W2396389010 hasRelatedWork W2369162477 @default.
- W2396389010 hasRelatedWork W2439875401 @default.
- W2396389010 hasRelatedWork W4238867864 @default.
- W2396389010 hasRelatedWork W2519357708 @default.
- W2396389010 hasRelatedWork W2525756941 @default.
- W2396389010 hasVolume "56" @default.
- W2396389010 isParatext "false" @default.
- W2396389010 isRetracted "false" @default.
- W2396389010 magId "2396389010" @default.
- W2396389010 workType "article" @default.