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- W2396392055 abstract "At low-tension DNA is well characterized by a simple worm-like chain model; however, application of tension above 60pN causes DNA to undergo a structural transition called the “overstretching transition”, characterized by a sharp, nearly 1.6x, increase in chain length. Despite nearly 20 years of continuing research, the origin and structure of DNA in the overstretched state has remained a fiercely debated topic. Central to the debate has been the argument as to whether overstretched DNA is characterized by strand separation (i.e. melted DNA, M-DNA) or a deformed, but still base-paired, form called S-DNA. Recent consensus has emerged that both forms co-exist and that base-pair interactions (A-T vs. G-C) likely dictate the structural motif. To further investigate this distinction, we compare the overstretching behavior of WT DNA with kilobase-length synthetic sequences having all A bases replaced by diaminopurine (DAP-DNA). DAP replacement yields DNA strands where every base-pair is maintained by 3 hydrogen bonds. Our work includes determination of the force required to overstretch DAP-DNA and a characterization of hysteresis under cyclic force application." @default.
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- W2396392055 date "2016-02-01" @default.
- W2396392055 modified "2023-10-16" @default.
- W2396392055 title "The Overstretching Transition of Diaminopurine Substituted Triply Hydrogen-Bonded DNA" @default.
- W2396392055 doi "https://doi.org/10.1016/j.bpj.2015.11.1023" @default.
- W2396392055 hasPublicationYear "2016" @default.
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