Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396462912> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2396462912 abstract "TGF-β responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. The ratio of TGF-β binding to TβR-II and TβR-I on the cell surface has recently been found to be a signal that controls TGF-β partitioning between these pathways. Since cholesterol is a structural component in lipid rafts/caveolae, we have studied the effects of cholesterol on TGF-β binding to TGF-β receptors and TGF-β responsiveness in cultured cells and in animals. Here we demonstrate that treatment with cholesterol decreases the TβR-II/TβR-I binding ratio of TGF-β while treatment with cholesterol-lowering or cholesterol-depleting agents increases the TβR-II/TβR-I binding ratio of TGF-β in all cell types studied. Cholesterol treatment increases accumulation of the TGF-β receptors in lipid rafts/caveolae microdomains of the plasma membrane. Cholesterol/LDL suppresses TGF-β responsiveness and statins/β-CD enhances it, as measured by the levels of P-Smad2 and PAI-1 expression. Furthermore, the cholesterol effects observed in cultured cells are also found in the aortic endothelium of atherosclerotic ApoE-null mice fed a high cholesterol diet. These results indicate that high plasma cholesterol levels contribute to the pathogenesis of atherosclerosis, at least in part, by suppressing TGF-β responsiveness." @default.
- W2396462912 created "2016-06-24" @default.
- W2396462912 creator A5047526614 @default.
- W2396462912 creator A5067607454 @default.
- W2396462912 creator A5089164683 @default.
- W2396462912 date "2008-03-01" @default.
- W2396462912 modified "2023-09-26" @default.
- W2396462912 title "Cholesterol Suppresses Cellular TGF‐beta Responsiveness by Increasing TGF‐beta Receptor Accumulation in Lipid raft/Caveolae Microdomains and Alterring TGF‐beta Binding to TGF‐beta Receptors" @default.
- W2396462912 doi "https://doi.org/10.1096/fasebj.22.1_supplement.645.7" @default.
- W2396462912 hasPublicationYear "2008" @default.
- W2396462912 type Work @default.
- W2396462912 sameAs 2396462912 @default.
- W2396462912 citedByCount "0" @default.
- W2396462912 crossrefType "journal-article" @default.
- W2396462912 hasAuthorship W2396462912A5047526614 @default.
- W2396462912 hasAuthorship W2396462912A5067607454 @default.
- W2396462912 hasAuthorship W2396462912A5089164683 @default.
- W2396462912 hasConcept C111001777 @default.
- W2396462912 hasConcept C118131993 @default.
- W2396462912 hasConcept C125555471 @default.
- W2396462912 hasConcept C126322002 @default.
- W2396462912 hasConcept C134018914 @default.
- W2396462912 hasConcept C170493617 @default.
- W2396462912 hasConcept C171020997 @default.
- W2396462912 hasConcept C185592680 @default.
- W2396462912 hasConcept C199360897 @default.
- W2396462912 hasConcept C2775960820 @default.
- W2396462912 hasConcept C2776174256 @default.
- W2396462912 hasConcept C2778229498 @default.
- W2396462912 hasConcept C41008148 @default.
- W2396462912 hasConcept C49866891 @default.
- W2396462912 hasConcept C55493867 @default.
- W2396462912 hasConcept C62478195 @default.
- W2396462912 hasConcept C71924100 @default.
- W2396462912 hasConcept C79266657 @default.
- W2396462912 hasConcept C86803240 @default.
- W2396462912 hasConcept C95444343 @default.
- W2396462912 hasConceptScore W2396462912C111001777 @default.
- W2396462912 hasConceptScore W2396462912C118131993 @default.
- W2396462912 hasConceptScore W2396462912C125555471 @default.
- W2396462912 hasConceptScore W2396462912C126322002 @default.
- W2396462912 hasConceptScore W2396462912C134018914 @default.
- W2396462912 hasConceptScore W2396462912C170493617 @default.
- W2396462912 hasConceptScore W2396462912C171020997 @default.
- W2396462912 hasConceptScore W2396462912C185592680 @default.
- W2396462912 hasConceptScore W2396462912C199360897 @default.
- W2396462912 hasConceptScore W2396462912C2775960820 @default.
- W2396462912 hasConceptScore W2396462912C2776174256 @default.
- W2396462912 hasConceptScore W2396462912C2778229498 @default.
- W2396462912 hasConceptScore W2396462912C41008148 @default.
- W2396462912 hasConceptScore W2396462912C49866891 @default.
- W2396462912 hasConceptScore W2396462912C55493867 @default.
- W2396462912 hasConceptScore W2396462912C62478195 @default.
- W2396462912 hasConceptScore W2396462912C71924100 @default.
- W2396462912 hasConceptScore W2396462912C79266657 @default.
- W2396462912 hasConceptScore W2396462912C86803240 @default.
- W2396462912 hasConceptScore W2396462912C95444343 @default.
- W2396462912 hasIssue "S1" @default.
- W2396462912 hasLocation W23964629121 @default.
- W2396462912 hasOpenAccess W2396462912 @default.
- W2396462912 hasPrimaryLocation W23964629121 @default.
- W2396462912 hasRelatedWork W1492150631 @default.
- W2396462912 hasRelatedWork W1503228526 @default.
- W2396462912 hasRelatedWork W1603332736 @default.
- W2396462912 hasRelatedWork W2014819127 @default.
- W2396462912 hasRelatedWork W2023985048 @default.
- W2396462912 hasRelatedWork W2055050914 @default.
- W2396462912 hasRelatedWork W2092804172 @default.
- W2396462912 hasRelatedWork W2246378037 @default.
- W2396462912 hasRelatedWork W2396462912 @default.
- W2396462912 hasRelatedWork W4240130371 @default.
- W2396462912 hasVolume "22" @default.
- W2396462912 isParatext "false" @default.
- W2396462912 isRetracted "false" @default.
- W2396462912 magId "2396462912" @default.
- W2396462912 workType "article" @default.