FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396487926> ?p ?o ?g. }

• W2396487926 endingPage "168" @default.
• W2396487926 startingPage "147" @default.
• W2396487926 abstract "HYTE (Hyeonggaeyeongyotang Extract), a polyherbal formula has been used as folk medicine, 28days repeat oral dose toxicity was tested in SD rats according to KFDA Guideline[2005-60]. Methods : In this study, mortality, clinical signs, body weight and gains, food and water consumption, ophthalmologic observation, urinalysis, hematology, serum biochemistry, gross findings, organ weight and histopathological observations were conducted during 28days of dosing periods. Results: 1. No HYTE treatment-related mortalities and clinical signs were detected in all dosing levels tested in male and female rats during the whole experimental periods. 2. No HYTE treatment-related changes on body weight, gains and food consumption were detected in all dosing levels tested in male and female rats during the whole experimental periods except for 2000mg/kg-dosing female groups in which significantly increase of body weight, gains, food and water consumption were detected compared to that of vehicle control in some points. 3. No HYTE treatment-related changes on ophthalmologic examination were detected in all dosing levels tested in male and female rats. 4. No HYTE treatment-related changes on urinalysis were detected in all dosing levels tested in male and female rats except for 2000mg/kg-dosing female groups in which, significantly increase of urine volume and related decrease on the urine specific gravity were detected as secondary effects of increase on the water consumptions not HYTE treatment-related toxicological signs. 5. No HYTE treatment-related changes on hematology were detected in all dosing levels tested in male and female rats except for increases in the total WBC count and lymphocytes of 2000mg/kg-dosing male and female groups with decrease of large unstained cells as pharmacological effects of immune enhancements not HYTE treatment-related toxicological signs. 6. No HYTE treatment-related changes on serum biochemistry were detected in all dosing levels tested in male and female rats. 7. No HYTE treatment-related changes on gross findings, organ weight and histopathology were detected in all dosing levels tested in male and female rats except for 2000mg/kg-dosing male and female groups in which, spleen and thymus organ weights, hypertrophy at gross observation and hyperpalsia of lymphoid cells and follicles at histopathological observation in spleen and thymus were detected as pharmacological effects of immune enhancements not HYTE treatment-related toxicological signs. Conclusions : Based on these results, the NOAEL and MTD of HYTE in SD rats were considered as over 2000mg/kg, respectively at 28days repeat oral dose toxicity test because most of these findings were considered as results of pharmacological effects of immune enhancements not HYTE treatment-related toxicological signs or secondary effects." @default.
• W2396487926 created "2016-06-24" @default.
• W2396487926 creator A5004687374 @default.
• W2396487926 creator A5016812908 @default.
• W2396487926 creator A5027287283 @default.
• W2396487926 creator A5032727979 @default.
• W2396487926 creator A5058818244 @default.
• W2396487926 date "2008-01-01" @default.
• W2396487926 modified "2023-09-24" @default.
• W2396487926 title "28days Repeat Oral Dose Toxicity Test of 'Hyeonggaeyeongyotang' extract in SD Rats" @default.
• W2396487926 hasPublicationYear "2008" @default.
• W2396487926 type Work @default.
• W2396487926 sameAs 2396487926 @default.
• W2396487926 citedByCount "1" @default.
• W2396487926 countsByYear W23964879262013 @default.
• W2396487926 crossrefType "journal-article" @default.
• W2396487926 hasAuthorship W2396487926A5004687374 @default.
• W2396487926 hasAuthorship W2396487926A5016812908 @default.
• W2396487926 hasAuthorship W2396487926A5027287283 @default.
• W2396487926 hasAuthorship W2396487926A5032727979 @default.
• W2396487926 hasAuthorship W2396487926A5058818244 @default.
• W2396487926 hasConcept C126322002 @default.
• W2396487926 hasConcept C147583825 @default.
• W2396487926 hasConcept C194409129 @default.
• W2396487926 hasConcept C2777288759 @default.
• W2396487926 hasConcept C2779225474 @default.
• W2396487926 hasConcept C2780026642 @default.
• W2396487926 hasConcept C29730261 @default.
• W2396487926 hasConcept C42407357 @default.
• W2396487926 hasConcept C71924100 @default.
• W2396487926 hasConcept C98274493 @default.
• W2396487926 hasConceptScore W2396487926C126322002 @default.
• W2396487926 hasConceptScore W2396487926C147583825 @default.
• W2396487926 hasConceptScore W2396487926C194409129 @default.
• W2396487926 hasConceptScore W2396487926C2777288759 @default.
• W2396487926 hasConceptScore W2396487926C2779225474 @default.
• W2396487926 hasConceptScore W2396487926C2780026642 @default.
• W2396487926 hasConceptScore W2396487926C29730261 @default.
• W2396487926 hasConceptScore W2396487926C42407357 @default.
• W2396487926 hasConceptScore W2396487926C71924100 @default.
• W2396487926 hasConceptScore W2396487926C98274493 @default.
• W2396487926 hasIssue "1" @default.
• W2396487926 hasLocation W23964879261 @default.
• W2396487926 hasOpenAccess W2396487926 @default.
• W2396487926 hasPrimaryLocation W23964879261 @default.
• W2396487926 hasRelatedWork W1594424602 @default.
• W2396487926 hasRelatedWork W1967967874 @default.
• W2396487926 hasRelatedWork W1971789981 @default.
• W2396487926 hasRelatedWork W1977565818 @default.
• W2396487926 hasRelatedWork W2009508675 @default.
• W2396487926 hasRelatedWork W2068786419 @default.
• W2396487926 hasRelatedWork W2214082295 @default.
• W2396487926 hasRelatedWork W2338189140 @default.
• W2396487926 hasRelatedWork W2375060590 @default.
• W2396487926 hasRelatedWork W2401841844 @default.
• W2396487926 hasRelatedWork W2404575695 @default.
• W2396487926 hasRelatedWork W2414011531 @default.
• W2396487926 hasRelatedWork W2418093514 @default.
• W2396487926 hasRelatedWork W2437631825 @default.
• W2396487926 hasRelatedWork W2465320190 @default.
• W2396487926 hasRelatedWork W2808957667 @default.
• W2396487926 hasRelatedWork W62430556 @default.
• W2396487926 hasRelatedWork W813993346 @default.
• W2396487926 hasRelatedWork W840856879 @default.
• W2396487926 hasRelatedWork W342352608 @default.
• W2396487926 hasVolume "16" @default.
• W2396487926 isParatext "false" @default.
• W2396487926 isRetracted "false" @default.
• W2396487926 magId "2396487926" @default.
• W2396487926 workType "article" @default.