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- W2396512120 abstract "We investigated ACE gene polymorphism in 80 patients with hypertrophic cardiomyopathy (HCM) and in 88 of their unaffected siblings and children. Genotypes were identified by polymerase chain reaction with oligonucleotide in intron 16 of the ACE gene. The D allele frequency was higher among patients with solitary HCM than among those with familial HCM. We also determined the expression of beta-adrenergic receptor kinase (beta ARK) mRNA in the heart in patients with congestive heart failure. beta ARK mRNA expression in failing heart was significantly increased compared with that in normal heart. These molecular biological methods such as investigation of ACE gene polymorphism and beta ARK mRNA expression are sufficient for detecting cardiac disease." @default.
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- W2396512120 date "1998-04-01" @default.
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- W2396512120 title "[Evaluation of cardiac function by biochemical and molecular biological techniques]." @default.
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