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- W2396539536 abstract "IntroductionAdrenal insufficient occurs in Human immunodeficiency virus (HIV)/ Acquired Immunodeficiency) Syndrome (AIDS) and causes morbidity and mortality} in HIV patients.ObjectiveTo determine cortisol levels and short term out come at 2 weeks in HIV infected and HIV uninfected patients admitted with sepsis in Kenyatta National hospital.DesignThis was a Cross Sectional Comparative study.SettingsMedical wards, Intensive Care Unit. Renal Units Kenyatta National Hospital.SubjectsPatients admitted with sepsis.MethodConsecutive HIV infected admitted with sepsis as defined by a tool adopted from the consensus conference held 2008 wore recruited. Male or female HIV infected patient s aged more than 13 years and their age and sex matched comparative HIV negative patients were included. A baseline cortisol test was done. Synthetic cosyntrophin was given intravenous!} To stimulate the adrenal glands and serum cortisol levels at 30 and 60 minutes done following the stimulation. Patients wore then followed until 2 weeks after admission to establish their outcome. Expected outcomes were either discharge from the hospital or death. P values of 0.005 were considered significant at confidence intervals of 95%. Adrenal insufficiency was defined as baseline cortisol levels 414nmol/l post stimulation.ResultsA total of 94 HIV infected and HIV uninfected patients wore recruited in the study 47 patients in each group. The mean age was 36=12.2 in the HIV infected group and 37= 13.4 HIV uninfected group. There was no statistically significant difference in the proportions of patients with adrenal insufficiency} in the two groups. The prevalence of primary adrenal insufficiency in the stud and comparative groups was 19% and 25.5% respectively.There were more deaths in the comparative group 31.9% compared to the study group at 24%.ConclusionThere was no significant difference of adrenal insufficiency in the study group and comparative group in the comparative group." @default.
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- W2396539536 date "2009-11-16" @default.
- W2396539536 modified "2023-09-23" @default.
- W2396539536 title "Cortisol levels and short term outcome in hiv infected patients with sepsis in Kenyatta Hospital" @default.
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