FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2396547575> ?p ?o ?g. }

• W2396547575 endingPage "50" @default.
• W2396547575 startingPage "41" @default.
• W2396547575 abstract "BALB/c mice were immunized with grass pollen extract (GPE), GPE conjugated to sodium alginate (Conjuvac) or GPE absorbed to aluminium hydroxide gel (alum). Conjuvac was a more potent immunogen than the other two preparations of GPE when anti-GPE IgG antibody levels were compared. In contrast, the highest IgE antibody titres in the Conjuvac treated mice, were some sixteen-fold lower than the highest titres in the mice immunized with GPE in alum. The suppressive effects of Conjuvac on IgE antibody titres were also studied. Mice were immunized with 1 microgram dinitrophenyl (DNP)-GPE in alum and the anti-DNP and anti-GPE IgE antibody titres determined. After 4 and 5 weeks, the mice were injected with GPE or Conjuvac. The Conjuvac and the GPE failed to reduce the ongoing primary anti-GPE IgE responses but both suppressed the secondary responses by up to eight-fold. The suppression was not dose-related however. The ongoing primary and secondary anti-DNP IgE titres were suppressed in a dose-related manner by up to sixty-four fold by Conjuvac but GPE treatment was much less suppressive. We went on to investigate the suppressive properties of DNR-alginate (DNP-alg) conjugates. In these experiments mice were immunized with 1 microgram DNP-ovalbumin (DNP-OA) mixed with alum. After 4 and 5 weeks, the mice were injected with a dose of 6--600 micrograms DNP-alg with an average hapten density of 2 or 10 per alginate molecule. After a further 8 weeks a second injection of 1 microgram DNP-OA was given. All dose levels of both DNP-alg conjugates suppressed the continuing primary as well as the secondary anti-DNP IgE responses. It is concluded that alginate has properties similar to those of known T-cell adjuvants and that Conjuvac may prove useful in the immunotherapy of atopic allergy." @default.
• W2396547575 created "2016-06-24" @default.
• W2396547575 creator A5032577937 @default.
• W2396547575 creator A5047528658 @default.
• W2396547575 creator A5057844469 @default.
• W2396547575 date "1981-09-01" @default.
• W2396547575 modified "2023-09-27" @default.
• W2396547575 title "Adjuvant and suppressive effects of Grass Conjuvac and other alginate conjugates on IgG and IgE antibody responses in mice." @default.
• W2396547575 cites W1486036223 @default.
• W2396547575 cites W1500873329 @default.
• W2396547575 cites W1504396091 @default.
• W2396547575 cites W1509235255 @default.
• W2396547575 cites W1530328828 @default.
• W2396547575 cites W1531956633 @default.
• W2396547575 cites W1532954927 @default.
• W2396547575 cites W1551530954 @default.
• W2396547575 cites W1553951911 @default.
• W2396547575 cites W1923696508 @default.
• W2396547575 cites W1976662981 @default.
• W2396547575 cites W1984201090 @default.
• W2396547575 cites W2005731849 @default.
• W2396547575 cites W2031592537 @default.
• W2396547575 cites W2038162224 @default.
• W2396547575 cites W2042007324 @default.
• W2396547575 cites W2062482845 @default.
• W2396547575 cites W2068569512 @default.
• W2396547575 cites W2069065778 @default.
• W2396547575 cites W2069817686 @default.
• W2396547575 cites W2085584249 @default.
• W2396547575 cites W2090947423 @default.
• W2396547575 cites W2137158717 @default.
• W2396547575 cites W2418776774 @default.
• W2396547575 cites W2614981795 @default.
• W2396547575 cites W2743983850 @default.
• W2396547575 cites W1569724029 @default.
• W2396547575 cites W1594956661 @default.
• W2396547575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1555132" @default.
• W2396547575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7275187" @default.
• W2396547575 hasPublicationYear "1981" @default.
• W2396547575 type Work @default.
• W2396547575 sameAs 2396547575 @default.
• W2396547575 citedByCount "0" @default.
• W2396547575 crossrefType "journal-article" @default.
• W2396547575 hasAuthorship W2396547575A5032577937 @default.
• W2396547575 hasAuthorship W2396547575A5047528658 @default.
• W2396547575 hasAuthorship W2396547575A5057844469 @default.
• W2396547575 hasConcept C134306372 @default.
• W2396547575 hasConcept C141105273 @default.
• W2396547575 hasConcept C147483822 @default.
• W2396547575 hasConcept C153911025 @default.
• W2396547575 hasConcept C159654299 @default.
• W2396547575 hasConcept C178790620 @default.
• W2396547575 hasConcept C185592680 @default.
• W2396547575 hasConcept C197336794 @default.
• W2396547575 hasConcept C202751555 @default.
• W2396547575 hasConcept C203014093 @default.
• W2396547575 hasConcept C2776946954 @default.
• W2396547575 hasConcept C2777863537 @default.
• W2396547575 hasConcept C2778177356 @default.
• W2396547575 hasConcept C2779909307 @default.
• W2396547575 hasConcept C2780924562 @default.
• W2396547575 hasConcept C29144244 @default.
• W2396547575 hasConcept C33923547 @default.
• W2396547575 hasConcept C51296783 @default.
• W2396547575 hasConcept C542903549 @default.
• W2396547575 hasConcept C55493867 @default.
• W2396547575 hasConcept C86803240 @default.
• W2396547575 hasConcept C98274493 @default.
• W2396547575 hasConceptScore W2396547575C134306372 @default.
• W2396547575 hasConceptScore W2396547575C141105273 @default.
• W2396547575 hasConceptScore W2396547575C147483822 @default.
• W2396547575 hasConceptScore W2396547575C153911025 @default.
• W2396547575 hasConceptScore W2396547575C159654299 @default.
• W2396547575 hasConceptScore W2396547575C178790620 @default.
• W2396547575 hasConceptScore W2396547575C185592680 @default.
• W2396547575 hasConceptScore W2396547575C197336794 @default.
• W2396547575 hasConceptScore W2396547575C202751555 @default.
• W2396547575 hasConceptScore W2396547575C203014093 @default.
• W2396547575 hasConceptScore W2396547575C2776946954 @default.
• W2396547575 hasConceptScore W2396547575C2777863537 @default.
• W2396547575 hasConceptScore W2396547575C2778177356 @default.
• W2396547575 hasConceptScore W2396547575C2779909307 @default.
• W2396547575 hasConceptScore W2396547575C2780924562 @default.
• W2396547575 hasConceptScore W2396547575C29144244 @default.
• W2396547575 hasConceptScore W2396547575C33923547 @default.
• W2396547575 hasConceptScore W2396547575C51296783 @default.
• W2396547575 hasConceptScore W2396547575C542903549 @default.
• W2396547575 hasConceptScore W2396547575C55493867 @default.
• W2396547575 hasConceptScore W2396547575C86803240 @default.
• W2396547575 hasConceptScore W2396547575C98274493 @default.
• W2396547575 hasIssue "1" @default.
• W2396547575 hasLocation W23965475751 @default.
• W2396547575 hasOpenAccess W2396547575 @default.
• W2396547575 hasPrimaryLocation W23965475751 @default.
• W2396547575 hasRelatedWork W1497157229 @default.
• W2396547575 hasRelatedWork W1826294690 @default.
• W2396547575 hasRelatedWork W1919959273 @default.
• W2396547575 hasRelatedWork W2007812018 @default.

• next